HitPredict

Interactor 1: PAN1 (P32521)
Actin cytoskeleton-regulatory complex protein PAN1 (Mitochondrial distribution of proteins protein 3)
Gene: PAN1

Interactor 2: ENT2 (Q05785)
Epsin-2
Gene: ENT2

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	32400111, 37968396
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000147 - actin cortical patch assembly GO:0005886 - plasma membrane GO:0006897 - endocytosis GO:0043332 - mating projection tip
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1480 Sc			1 613
+	Sc
		692257 PAN1_YEAST (1-1475): 2.89e-108: 379: 100.00		ENT1_YEAST (1-514): 2.63e-90: 288: 50.97
+	Ce
		1259347 Q8WSP1_CAEEL (232-693): 1.18e-60: 222: 15.31		Q9BI72_CAEEL (3-468): 5.43e-85: 275: 19.71
+	Hs
		1349324 EHD2_HUMAN (229-695): 4.13e-62: 224: 14.02		EPN1_HUMAN (2-542): 1.93e-82: 271: 18.89
+	Hs
		1331796 EHD1_HUMAN (232-691): 9.44e-62: 223: 15.67		EPN1_HUMAN (2-542): 1.93e-82: 271: 18.89
+	Mm
		1194350 EHD2_MOUSE (229-695): 6.31e-62: 223: 13.82		EPN1_MOUSE (2-542): 5.92e-82: 270: 19.10
+	Mm
		1194352 EHD1_MOUSE (232-691): 9.2e-61: 220: 15.67		EPN1_MOUSE (2-542): 5.92e-82: 270: 19.10
+	Hs
		1328941 EHD2_HUMAN (229-695): 4.13e-62: 224: 14.02		EPN3_HUMAN (2-576): 4.5e-76: 256: 18.21
+	Hs
		1328938 EHD1_HUMAN (232-691): 9.44e-62: 223: 15.67		EPN3_HUMAN (2-576): 4.5e-76: 256: 18.21
+	Sc
		710409 EDE1_YEAST (161-1466): 8.57e-45: 180: 11.56		ENT1_YEAST (1-514): 2.63e-90: 288: 50.97
+	Mm
		1206518 EHD2_MOUSE (229-695): 6.31e-62: 223: 13.82		EPN3_MOUSE (2-565): 1.66e-66: 230: 18.04
+	Dm
		91160 E3CTP7_DROME (274-1025): 2.19e-53: 203: 14.73		Q7KU90_DROME (5-606): 5.78e-72: 249: 20.57
+	Mm
		1265097 EHD1_MOUSE (232-691): 9.2e-61: 220: 15.67		EPN3_MOUSE (2-565): 1.66e-66: 230: 18.04
+	Mm
		1194353 ITSN1_MOUSE (44-941): 8.17e-27: 121: 11.17		EPN1_MOUSE (2-542): 5.92e-82: 270: 19.10
+	Hs
		787913 EPS15_HUMAN (139-487): 2.65e-18: 93.4: 16.91		EPN4_HUMAN (3-575): 9.26e-84: 276: 16.80
+	Hs
		1078919 ITSN2_HUMAN (43-386): 1.13e-39: 163: 16.07		ITSN1_HUMAN (123-593): 6.84e-49: 186: 15.39
+	Hs
		1078828 ITSN1_HUMAN (44-1122): 3.88e-32: 139: 10.35		ITSN1_HUMAN (123-593): 6.84e-49: 186: 15.39
+	Cl
		47357 A0A8I3PJA6_CANLF (576-1274): 1.21e-31: 136: 12.23		F1PHV6_CANLF (123-593): 5.94e-48: 183: 14.63
+	Hs
		787920 EPS15_HUMAN (139-487): 2.65e-18: 93.4: 16.91		ITSN1_HUMAN (123-593): 6.84e-49: 186: 15.39
+	Hs
		307533 ITSN1_HUMAN (44-1122): 3.88e-32: 139: 10.35		EPN2_HUMAN (182-557): 9.06e-16: 82.8: 10.03
+	Dm
		113976 M9PB30_DROME (81-863): 4.9e-23: 109: 9.71		M9PB30_DROME (157-613): 2.69e-09: 62.7: 7.50