HitPredict

Interactor 1: RPD3 (P32561)
Histone deacetylase RPD3 (EC 3.5.1.98) (Transcriptional regulatory protein RPD3)
Gene: RPD3

Interactor 2: H3 (P61830)
Histone H3
Gene: HHT1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.680

Property	Details
Experiments	21646424, 22177115, 22199229, 22922743
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006355 - regulation of DNA-templated transcription
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 433 Sc			1 136
+	Hs
		934735 HDAC1_HUMAN (15-428): 0: 598: 60.87		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		952319 HDAC1_HUMAN (15-428): 0: 598: 60.87		H33_HUMAN (1-136): 1.25e-61: 187: 90.44
+	Hs
		1038423 HDAC1_HUMAN (15-428): 0: 598: 60.87		H31T_HUMAN (1-136): 1.96e-61: 186: 86.03
+	Hs
		111560 HDAC1_HUMAN (15-428): 0: 598: 60.87		K7EK07_HUMAN (1-132): 8.05e-60: 182: 90.91
+	Hs
		935063 HDAC2_HUMAN (18-432): 0: 583: 61.69		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		952512 HDAC2_HUMAN (18-432): 0: 583: 61.69		H33_HUMAN (1-136): 1.25e-61: 187: 90.44
+	Hs
		1086250 HDAC2_HUMAN (18-432): 0: 583: 61.69		H31T_HUMAN (1-136): 1.96e-61: 186: 86.03
+	Hs
		828220 HDAC1_HUMAN (15-428): 0: 598: 60.87		CENPA_HUMAN (9-133): 2.55e-40: 133: 47.73
+	At
		886469 HDA6_ARATH (1-431): 0: 543: 55.43		H33_ARATH (1-136): 4.81e-62: 187: 87.50
+	Hs
		177255 HDAC3_HUMAN (19-433): 0: 534: 57.31		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Mm
		952773 Q9JM08_MOUSE (19-433): 0: 529: 56.84		H33_MOUSE (1-136): 1.25e-61: 187: 90.44
+	Ce
		184839 HDA1_CAEEL (18-433): 0: 553: 58.00		HCP3_CAEEL (11-131): 7.82e-44: 146: 46.77
+	Sp
		140575 PHD1_SCHPO (4-414): 3.57e-179: 508: 50.60		H31_SCHPO (1-136): 1.17e-59: 182: 92.65
+	Sc
		859059 HOS2_YEAST (3-430): 3.66e-168: 481: 45.04		H3_YEAST (1-136): 1.51e-56: 174: 100.00
+	Hs
		935199 HDAC8_HUMAN (5-383): 3.01e-144: 417: 40.26		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		1086303 HDAC8_HUMAN (5-383): 3.01e-144: 417: 40.26		H31T_HUMAN (1-136): 1.96e-61: 186: 86.03
+	Sc
		866875 HDA1_YEAST (8-340): 3.39e-120: 367: 25.21		H3_YEAST (1-136): 1.51e-56: 174: 100.00
+	Hs
		935331 HDAC6_HUMAN (21-331): 1.58e-90: 299: 23.84		H31_HUMAN (1-136): 3.24e-62: 188: 88.97