HitPredict

Interactor 1: RPD3 (P32561)
Histone deacetylase RPD3 (EC 3.5.1.98) (Transcriptional regulatory protein RPD3)
Gene: RPD3

Interactor 2: NHP10 (Q03435)
Non-histone protein 10 (High mobility group protein 2)
Gene: NHP10

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36888706
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006355 - regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 433 Sc			1 203
+	Hs
		1038645 HDAC1_HUMAN (15-428): 0: 598: 60.87		CIC_HUMAN (44-201): 6.64e-29: 114: 16.76
+	Hs
		297491 HDAC1_HUMAN (15-428): 0: 598: 60.87		TOX4_HUMAN (51-199): 4.76e-28: 112: 18.82
+	Hs
		818023 HDAC1_HUMAN (15-428): 0: 598: 60.87		SOX2_HUMAN (63-178): 1.49e-29: 112: 15.00
+	Mm
		140273 HDAC1_MOUSE (15-428): 0: 598: 61.11		Q60I23_MOUSE (62-178): 5.5e-29: 111: 14.88
+	Hs
		883315 HDAC1_HUMAN (15-428): 0: 598: 60.87		SOX8_HUMAN (52-196): 3.14e-28: 111: 14.91
+	Mm
		140241 HDAC1_MOUSE (15-428): 0: 598: 61.11		SOX2_MOUSE (62-178): 1.12e-28: 110: 14.88
+	Hs
		1038764 HDAC1_HUMAN (15-428): 0: 598: 60.87		HM20B_HUMAN (68-196): 1.37e-26: 105: 19.55
+	Hs
		1270390 HDAC2_HUMAN (18-432): 0: 583: 61.69		CIC_HUMAN (44-201): 6.64e-29: 114: 16.76
+	Hs
		818314 HDAC2_HUMAN (18-432): 0: 583: 61.69		SOX2_HUMAN (63-178): 1.49e-29: 112: 15.00
+	Mm
		936399 HDAC2_MOUSE (18-432): 0: 581: 61.45		Q60I23_MOUSE (62-178): 5.5e-29: 111: 14.88
+	Mm
		818688 HDAC2_MOUSE (18-432): 0: 581: 61.45		SOX2_MOUSE (62-178): 1.12e-28: 110: 14.88
+	Hs
		1270484 HDAC2_HUMAN (18-432): 0: 583: 61.69		HM20B_HUMAN (68-196): 1.37e-26: 105: 19.55
+	Hs
		449714 HDAC1_HUMAN (15-428): 0: 598: 60.87		HMGB1_HUMAN (80-160): 1.31e-19: 84.5: 31.77
+	Dm
		1098074 HDAC1_DROME (15-432): 0: 586: 59.57		HMG2_DROME (77-185): 1.53e-11: 64.4: 18.26
+	Hs
		177229 HDAC3_HUMAN (19-433): 0: 534: 57.31		SOX2_HUMAN (63-178): 1.49e-29: 112: 15.00
+	Mm
		1142019 Q9JM08_MOUSE (19-433): 0: 529: 56.84		Q60I23_MOUSE (62-178): 5.5e-29: 111: 14.88
+	Zm
		6820 A0A1D6EBQ1_MAIZE (25-433): 0: 515: 51.03		A0A1D6EUM9_MAIZE (83-192): 4.32e-28: 105: 20.00
+	Mm
		927928 HDAC4_MOUSE (1-418): 6.97e-134: 412: 22.77		HMGB1_MOUSE (80-160): 1.31e-19: 84.5: 31.77
+	Hs
		449621 HDAC4_HUMAN (1-418): 7.15e-130: 402: 22.96		HMGB1_HUMAN (80-160): 1.31e-19: 84.5: 31.77
+	Hs
		643280 HDAC4_HUMAN (1-418): 7.15e-130: 402: 22.96		HMGB2_HUMAN (92-160): 6.72e-16: 74.5: 27.40