HitPredict

Interactor 1: VPP1 (P32563)
V-type proton ATPase subunit a, vacuolar isoform (V-ATPase a 1 subunit) (V-ATPase 95 kDa subunit) (Vacuolar pH protein 1) (Vacuolar proton pump a subunit) (Vacuolar proton translocating ATPase subunit a 1)
Gene: VPH1

Interactor 2: VATG (P48836)
V-type proton ATPase subunit G (V-ATPase subunit G) (V-ATPase 13 kDa subunit) (Vacuolar proton pump subunit G)
Gene: VMA10

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.937

Property	Details
Experiments	11592965, 19081055, 34918374, 37968396, 23071676, 23142977
Identification Methods	coimmunoprecipitation, anti tag coimmunoprecipitation, affinity chromatography technology, unspecified method, x-ray crystallography
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	V-ATPase_G~V_ATPase_I
Common GO terms	GO:0000329 - fungal-type vacuole membrane GO:0007035 - vacuolar acidification GO:0016471 - vacuolar proton-transporting V-type ATPase complex GO:0046961 - proton-transporting ATPase activity, rotational mechanism GO:1902600 - proton transmembrane transport
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 840 Sc			1 114
+	Mm
		1321784 VPP1_MOUSE (8-824): 0: 1233: 40.00		VATG1_MOUSE (2-112): 6.62e-29: 102: 37.84
+	Mm
		1376699 VPP1_MOUSE (8-824): 0: 1233: 40.00		VATG2_MOUSE (2-112): 1.08e-25: 94.4: 32.43
+	Hs
		260090 VPP1_HUMAN (8-824): 0: 1220: 40.21		VATG1_HUMAN (2-112): 1.57e-27: 99.1: 37.84
+	Hs
		318296 VPP1_HUMAN (8-824): 0: 1220: 40.21		VATG2_HUMAN (2-112): 3.08e-26: 96: 32.43
+	Hs
		318304 VPP2_HUMAN (7-822): 0: 1152: 36.59		VATG2_HUMAN (2-112): 3.08e-26: 96: 32.43
+	Hs
		318284 VPP3_HUMAN (7-826): 0: 1034: 35.75		VATG2_HUMAN (2-112): 3.08e-26: 96: 32.43
+	Sc
		741308 VPP2_YEAST (4-824): 0: 987: 49.10		VATG_YEAST (1-114): 2.45e-23: 88.3: 100.00