HitPredict

Interactor 1: RPN2 (P32565)
26S proteasome regulatory subunit RPN2
Gene: RPN2

Interactor 2: PSB1 (P38624)
Proteasome subunit beta type-1 (EC 3.4.25.1) (Macropain subunit PRE3) (Multicatalytic endopeptidase complex subunit PRE3) (Proteasome component PRE3) (Proteinase YSCE subunit PRE3)
Gene: PRE3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	16429126, 37968396
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0034515 - proteasome storage granule GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 945 Sc			1 215
+	Hs
		656638 PSMD1_HUMAN (3-926): 0: 1116: 39.98		PSB6_HUMAN (15-212): 3.92e-82: 245: 55.78
+	Hs
		656297 PSMD1_HUMAN (3-926): 0: 1116: 39.98		PSA5_HUMAN (5-215): 1e-74: 227: 15.32
+	Hs
		656133 PSMD1_HUMAN (3-926): 0: 1116: 39.98		PSB9_HUMAN (9-211): 2.36e-74: 225: 45.10
+	Hs
		638180 PSMD1_HUMAN (3-926): 0: 1116: 39.98		PSA4_HUMAN (5-215): 9.98e-73: 223: 15.46
+	Sc
		625919 RPN2_YEAST (1-945): 0: 1119: 100.00		PSB2_YEAST (2-214): 1.18e-69: 214: 26.73
+	Sc
		675399 RPN2_YEAST (1-945): 0: 1119: 100.00		PSB5_YEAST (13-209): 4.66e-69: 214: 27.14
+	Sc
		619340 RPN2_YEAST (1-945): 0: 1119: 100.00		PSA3_YEAST (5-215): 4.55e-69: 213: 17.20
+	Hs
		656760 PSMD1_HUMAN (3-926): 0: 1116: 39.98		PSB5_HUMAN (14-205): 3.86e-70: 216: 27.32
+	Hs
		893734 PSMD1_HUMAN (3-926): 0: 1116: 39.98		PSA6_HUMAN (5-214): 5.29e-70: 215: 16.90
+	Hs
		1303479 PSMD1_HUMAN (3-926): 0: 1116: 39.98		PSB7_HUMAN (17-209): 1.35e-68: 213: 30.93
+	Hs
		156342 PSMD1_HUMAN (3-926): 0: 1116: 39.98		PSA7_HUMAN (6-214): 3.71e-69: 213: 16.13
+	Hs
		690 A0A087WW66_HUMAN (3-926): 0: 1016: 36.69		PSB6_HUMAN (15-212): 3.92e-82: 245: 55.78
+	Hs
		689 A0A087WW66_HUMAN (3-926): 0: 1016: 36.69		PSA5_HUMAN (5-215): 1e-74: 227: 15.32
+	Hs
		688 A0A087WW66_HUMAN (3-926): 0: 1016: 36.69		PSA4_HUMAN (5-215): 9.98e-73: 223: 15.46
+	Hs
		691 A0A087WW66_HUMAN (3-926): 0: 1016: 36.69		PSB5_HUMAN (14-205): 3.86e-70: 216: 27.32
+	Hs
		699 A0A087WW66_HUMAN (3-926): 0: 1016: 36.69		PSA6_HUMAN (5-214): 5.29e-70: 215: 16.90
+	Hs
		710 A0A087WW66_HUMAN (3-926): 0: 1016: 36.69		PSB7_HUMAN (17-209): 1.35e-68: 213: 30.93
+	Dm
		47613 PSMD1_DROME (1-927): 0: 990: 36.04		A0AQH0_DROME (4-211): 7.77e-79: 237: 53.11
+	Dm
		1278636 PSMD1_DROME (1-927): 0: 990: 36.04		PSA5_DROME (5-214): 4.91e-74: 225: 17.94
+	Dm
		1178951 PSMD1_DROME (1-927): 0: 990: 36.04		Q7K148_DROME (1-202): 4.76e-71: 219: 26.83