HitPredict

Interactor 1: RPN2 (P32565)
26S proteasome regulatory subunit RPN2
Gene: RPN2

Interactor 2: RPN8 (Q08723)
26S proteasome regulatory subunit RPN8
Gene: RPN8

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.922

Property	Details
Experiments	16554755, 37968396, 22940862, 16429126, 14759368
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HEAT_2~MitMem_reg, JAB~PC_rep
Common GO terms	GO:0000502 - proteasome complex GO:0006511 - ubiquitin-dependent protein catabolic process GO:0034515 - proteasome storage granule GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 945 Sc			1 338
+	Hs
		849257 PSMD1_HUMAN (3-926): 0: 1116: 39.98		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Hs
		696 A0A087WW66_HUMAN (3-926): 0: 1016: 36.69		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Dm
		640780 PSMD1_DROME (1-927): 0: 990: 36.04		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Sp
		251846 RPN2_SCHPO (3-938): 0: 1002: 41.56		RPN11_SCHPO (1-263): 3.34e-61: 199: 19.11
+	Dm
		1358666 PSMD1_DROME (1-927): 0: 990: 36.04		PSDE_DROME (3-264): 6.45e-48: 165: 16.90
+	Hs
		849192 PSMD2_HUMAN (9-770): 0: 760: 17.31		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	At
		1320083 PSD2A_ARATH (9-770): 0: 669: 17.76		PSD7B_ARATH (6-311): 1.9e-100: 300: 49.03
+	At
		188942 PSD2A_ARATH (9-770): 0: 669: 17.76		PSD7A_ARATH (6-308): 6.55e-100: 298: 49.18
+	Dm
		640795 Q9VW54_DROME (13-770): 0: 651: 17.61		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Sp
		251461 RPN1_SCHPO (9-770): 0: 621: 18.33		RPN8_SCHPO (5-321): 6.04e-99: 296: 50.78
+	At
		1339597 PSD2A_ARATH (9-770): 0: 669: 17.76		PSDE_ARATH (3-263): 1.25e-46: 161: 17.65
+	Sp
		784766 RPN1_SCHPO (9-770): 0: 621: 18.33		RPN11_SCHPO (1-263): 3.34e-61: 199: 19.11
+	Dm
		1358676 Q9VW54_DROME (13-770): 0: 651: 17.61		PSDE_DROME (3-264): 6.45e-48: 165: 16.90
+	Sc
		753971 RPN1_YEAST (9-573): 1.13e-134: 430: 17.33		RPN8_YEAST (1-338): 6.52e-119: 348: 100.00