HitPredict

Interactor 1: MED17 (P32569)
Mediator of RNA polymerase II transcription subunit 17 (Mediator complex subunit 17) (Suppressor of RNA polymerase B 4)
Gene: SRB4

Interactor 2: MED4 (Q12343)
Mediator of RNA polymerase II transcription subunit 4 (Mediator complex subunit 4)
Gene: MED4

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.90	0.921

The method score is based on:

Property	Details
Experiments	9420330, 11555651, 16554755, 16429126, 28575439, 18381891, 19077037, 33933450, 37968396, 23135281
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Med17~Med4
Common GO terms	GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding GO:0003712 - transcription coregulator activity GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0016592 - mediator complex and 4 others more... GO:0032968 - positive regulation of transcription elongation by RNA polymerase II GO:0051123 - RNA polymerase II preinitiation complex assembly GO:0060261 - positive regulation of transcription initiation by RNA polymerase II GO:0070847 - core mediator complex
Homologous interactions	0

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024