HitPredict

Interactor 1: PUB1 (P32588)
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1 (ARS consensus-binding protein ACBP-60) (Poly uridylate-binding protein) (Poly(U)-binding protein)
Gene: PUB1

Interactor 2: LHP1 (P33399)
La protein homolog (La autoantigen homolog) (La ribonucleoprotein)
Gene: LHP1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.759

Property	Details
Experiments	11805826, 16429126
Identification Methods	tandem affinity purification, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	La~RRM_1, RRM_1~RRM_1
Common GO terms	GO:0003729 - mRNA binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 453 Sc			1 275
+	Sc
		376709 PABP_YEAST (2-344): 4.03e-48: 175: 18.66		LHP1_YEAST (1-275): 7.7e-72: 223: 100.00
+	At
		285476 PABP2_ARATH (43-245): 3.58e-47: 173: 25.00		LRP6B_ARATH (1-274): 3.82e-59: 198: 18.75
+	Sc
		694294 PUB1_YEAST (1-441): 7.49e-91: 284: 100.00		SLF1_YEAST (23-89): 4.92e-13: 70.4: 33.80
+	At
		790116 PABP2_ARATH (43-245): 3.58e-47: 173: 25.00		LRP6C_ARATH (27-259): 2.82e-50: 173: 18.55
+	Hs
		1116542 PABP3_HUMAN (152-427): 1.76e-38: 149: 18.75		LARP7_HUMAN (23-274): 2.4e-49: 173: 22.84
+	At
		285478 PABP8_ARATH (6-173): 2.07e-21: 99.2: 17.44		LRP6B_ARATH (1-274): 3.82e-59: 198: 18.75
+	Hs
		1073582 SF3B4_HUMAN (74-243): 3.99e-20: 94: 31.40		LARP7_HUMAN (23-274): 2.4e-49: 173: 22.84
+	Hs
		1031352 PABP4_HUMAN (6-167): 2.17e-18: 90: 15.34		LARP7_HUMAN (23-274): 2.4e-49: 173: 22.84
+	Hs
		1116304 PAP1L_HUMAN (6-167): 1.11e-17: 87.6: 17.18		LARP7_HUMAN (23-274): 2.4e-49: 173: 22.84
+	Hs
		516541 PABP1_HUMAN (6-167): 3.88e-17: 86.1: 15.85		LARP7_HUMAN (23-274): 2.4e-49: 173: 22.84
+	Hs
		403212 PABP4_HUMAN (6-167): 2.17e-18: 90: 15.34		LA_HUMAN (29-275): 1.12e-48: 167: 19.92
+	Sc
		376965 PABP_YEAST (2-344): 4.03e-48: 175: 18.66		SLF1_YEAST (23-89): 4.92e-13: 70.4: 33.80
+	Hs
		516568 PABP1_HUMAN (6-167): 3.88e-17: 86.1: 15.85		LARP4_HUMAN (19-202): 1.2e-37: 142: 17.20
+	Hs
		1031407 PABP4_HUMAN (6-167): 2.17e-18: 90: 15.34		LAR4B_HUMAN (9-214): 2.84e-36: 138: 17.79
+	Hs
		516616 PABP1_HUMAN (6-167): 3.88e-17: 86.1: 15.85		LAR4B_HUMAN (9-214): 2.84e-36: 138: 17.79
+	Hs
		474033 PAB4L_HUMAN (6-153): 3.24e-17: 85: 16.11		LAR4B_HUMAN (9-214): 2.84e-36: 138: 17.79
+	Hs
		1031367 PABP4_HUMAN (6-167): 2.17e-18: 90: 15.34		LARP1_HUMAN (26-274): 6.71e-25: 105: 15.20
+	Dm
		597071 PABP_DROME (1-165): 1.37e-17: 87.3: 21.56		LARP_DROME (29-149): 2.62e-25: 106: 24.59
+	Hs
		516561 PABP1_HUMAN (6-167): 3.88e-17: 86.1: 15.85		LARP1_HUMAN (26-274): 6.71e-25: 105: 15.20
+	Hs
		516553 PABP1_HUMAN (6-167): 3.88e-17: 86.1: 15.85		LAR1B_HUMAN (29-124): 4.85e-21: 94.6: 25.77