HitPredict

Interactor 1: HSP7F (P32589)
Heat shock protein homolog SSE1 (Chaperone protein MSI3)
Gene: SSE1

Interactor 2: UFD4 (P33202)
Ubiquitin fusion degradation protein 4 (UB fusion protein 4) (EC 2.3.2.-) (HECT-type E3 ubiquitin transferase UFD4) (EC 2.3.2.26)
Gene: UFD4

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	19536198
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 693 Sc			1 1483
+	Hs
		125115 HSP7C_HUMAN (2-645): 0: 851: 27.04		WWP2_HUMAN (610-1480): 0: 722: 16.39
+	Sc
		493555 HSP72_YEAST (1-382): 1.15e-71: 246: 36.82		UFD4_YEAST (1-1483): 0: 1249: 100.00
+	Sc
		490757 HSP71_YEAST (1-382): 7.01e-71: 244: 36.55		UFD4_YEAST (1-1483): 0: 1249: 100.00
+	Hs
		504580 HSP7C_HUMAN (2-645): 0: 851: 27.04		ITCH_HUMAN (827-1480): 0: 614: 17.64
+	Sc
		695389 HSP7F_YEAST (1-693): 0: 829: 100.00		TOM1_YEAST (595-1483): 1.37e-167: 562: 16.87
+	Hs
		504792 HSP7C_HUMAN (2-645): 0: 851: 27.04		SMUF1_HUMAN (965-1479): 4.08e-162: 509: 17.15
+	Hs
		504222 HSP7C_HUMAN (2-645): 0: 851: 27.04		HECD2_HUMAN (779-1481): 2.21e-158: 500: 17.74
+	Hs
		125610 HS105_HUMAN (6-687): 1.23e-133: 416: 36.05		WWP2_HUMAN (610-1480): 0: 722: 16.39
+	Hs
		503946 HSP7C_HUMAN (2-645): 0: 851: 27.04		UBE3A_HUMAN (1204-1482): 2.39e-21: 103: 29.17
+	Hs
		504318 HSP7C_HUMAN (2-645): 0: 851: 27.04		HUWE1_HUMAN (1191-1483): 1.44e-20: 101: 31.51
+	Hs
		871538 HSP72_HUMAN (2-644): 0: 840: 27.08		UBE3A_HUMAN (1204-1482): 2.39e-21: 103: 29.17
+	Sc
		494807 HSP72_YEAST (1-382): 1.15e-71: 246: 36.82		TOM1_YEAST (595-1483): 1.37e-167: 562: 16.87
+	Sc
		494037 HSP72_YEAST (1-382): 1.15e-71: 246: 36.82		RSP5_YEAST (774-1480): 1.01e-176: 550: 15.57
+	Sc
		491309 HSP71_YEAST (1-382): 7.01e-71: 244: 36.55		RSP5_YEAST (774-1480): 1.01e-176: 550: 15.57
+	Hs
		714462 HSP74_HUMAN (6-650): 5.45e-136: 421: 38.47		HECD1_HUMAN (1277-1475): 3.61e-27: 123: 35.44
+	Hs
		320926 HS74L_HUMAN (6-650): 1.32e-134: 418: 35.85		HECD1_HUMAN (1277-1475): 3.61e-27: 123: 35.44
+	Hs
		1267779 HS105_HUMAN (6-687): 1.23e-133: 416: 36.05		HECD1_HUMAN (1277-1475): 3.61e-27: 123: 35.44
+	Hs
		714194 HSP74_HUMAN (6-650): 5.45e-136: 421: 38.47		UBE3A_HUMAN (1204-1482): 2.39e-21: 103: 29.17
+	Hs
		714284 HSP74_HUMAN (6-650): 5.45e-136: 421: 38.47		HUWE1_HUMAN (1191-1483): 1.44e-20: 101: 31.51
+	Hs
		1192142 HS105_HUMAN (6-687): 1.23e-133: 416: 36.05		HUWE1_HUMAN (1191-1483): 1.44e-20: 101: 31.51