HitPredict

Interactor 1: HSP7F (P32589)
Heat shock protein homolog SSE1 (Chaperone protein MSI3)
Gene: SSE1

Interactor 2: RPN11 (P43588)
Ubiquitin carboxyl-terminal hydrolase RPN11 (EC 3.4.19.12) (26S proteasome regulatory subunit RPN11) (Protein MPR1)
Gene: RPN11

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.672

Property	Details
Experiments	16284124, 18757749, 20170199, 19536198
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 693 Sc			1 306
+	Hs
		130712 HSP7C_HUMAN (2-645): 0: 851: 27.04		PSDE_HUMAN (16-306): 2.53e-98: 293: 67.35
+	Hs
		504512 HSP7C_HUMAN (2-645): 0: 851: 27.04		CSN5_HUMAN (14-292): 7.24e-75: 234: 30.74
+	Hs
		714039 HS71L_HUMAN (2-646): 0: 848: 26.69		CSN5_HUMAN (14-292): 7.24e-75: 234: 30.74
+	Hs
		564143 HSP76_HUMAN (4-643): 0: 842: 26.28		CSN5_HUMAN (14-292): 7.24e-75: 234: 30.74
+	Hs
		124744 HSP7C_HUMAN (2-645): 0: 851: 27.04		EIF3F_HUMAN (3-305): 7.75e-56: 186: 14.24
+	Sc
		695695 HSP7F_YEAST (1-693): 0: 829: 100.00		RPN8_YEAST (25-305): 6.68e-51: 172: 16.03
+	Hs
		130766 HSP74_HUMAN (6-650): 5.45e-136: 421: 38.47		PSDE_HUMAN (16-306): 2.53e-98: 293: 67.35
+	Hs
		130680 HS74L_HUMAN (6-650): 1.32e-134: 418: 35.85		PSDE_HUMAN (16-306): 2.53e-98: 293: 67.35
+	Hs
		131024 HS105_HUMAN (6-687): 1.23e-133: 416: 36.05		PSDE_HUMAN (16-306): 2.53e-98: 293: 67.35
+	Hs
		714341 HSP74_HUMAN (6-650): 5.45e-136: 421: 38.47		CSN5_HUMAN (14-292): 7.24e-75: 234: 30.74
+	Hs
		320891 HS74L_HUMAN (6-650): 1.32e-134: 418: 35.85		CSN5_HUMAN (14-292): 7.24e-75: 234: 30.74
+	Hs
		1267726 HS105_HUMAN (6-687): 1.23e-133: 416: 36.05		CSN5_HUMAN (14-292): 7.24e-75: 234: 30.74
+	Sc
		450086 HSP73_YEAST (1-642): 5.45e-72: 247: 28.33		RPN11_YEAST (1-306): 4.59e-91: 274: 100.00
+	Sc
		494264 HSP72_YEAST (1-382): 1.15e-71: 246: 36.82		RPN11_YEAST (1-306): 4.59e-91: 274: 100.00
+	Sc
		491597 HSP71_YEAST (1-382): 7.01e-71: 244: 36.55		RPN11_YEAST (1-306): 4.59e-91: 274: 100.00
+	Sc
		495175 HSP72_YEAST (1-382): 1.15e-71: 246: 36.82		RPN8_YEAST (25-305): 6.68e-51: 172: 16.03
+	Sc
		492686 HSP71_YEAST (1-382): 7.01e-71: 244: 36.55		RPN8_YEAST (25-305): 6.68e-51: 172: 16.03