HitPredict

Interactor 1: SEC17 (P32602)
Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) (Vesicular-fusion protein SEC17) (alpha-SNAP chaperone)
Gene: SEC17

Interactor 2: SED5 (Q01590)
Integral membrane protein SED5
Gene: SED5

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.935

Property	Details
Experiments	9427746, 9398683, 12729020, 7923363, 16107716, 17522384
Identification Methods	coimmunoprecipitation, affinity chromatography technology, biochemical, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNAP~SNARE
Common GO terms	GO:0006886 - intracellular protein transport GO:0031201 - SNARE complex GO:0048280 - vesicle fusion with Golgi apparatus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 292 Sc			1 340
+	Dm
		1095553 SNAP_DROME (3-289): 9.54e-100: 295: 32.40		STX5_DROME (1-325): 2.73e-60: 201: 30.77
+	Hs
		1027559 SNAB_HUMAN (3-289): 1.36e-101: 300: 33.80		STX5_HUMAN (1-324): 1.36e-52: 178: 29.01
+	Hs
		1083986 SNAB_HUMAN (3-289): 1.36e-101: 300: 33.80		STX1A_HUMAN (85-337): 2.07e-53: 178: 12.89
+	Mm
		192858 SNAA_MOUSE (12-291): 1.23e-100: 298: 35.00		STX1A_MOUSE (85-337): 3.85e-54: 180: 13.28
+	Rn
		699171 SNAA_RAT (12-291): 8.12e-101: 298: 35.00		STX1A_RAT (85-337): 5.79e-54: 180: 13.28
+	Hs
		873539 SNAA_HUMAN (12-291): 5.14e-101: 299: 35.00		STX5_HUMAN (1-324): 1.36e-52: 178: 29.01
+	Hs
		873547 SNAA_HUMAN (12-291): 5.14e-101: 299: 35.00		STX1A_HUMAN (85-337): 2.07e-53: 178: 12.89
+	Hs
		699286 SNAB_HUMAN (3-289): 1.36e-101: 300: 33.80		STX2_HUMAN (84-339): 1.55e-52: 176: 13.57
+	Hs
		898845 SNAB_HUMAN (3-289): 1.36e-101: 300: 33.80		STX1B_HUMAN (85-337): 2.67e-52: 176: 12.55
+	Dm
		1095554 SNAP_DROME (3-289): 9.54e-100: 295: 32.40		STX1A_DROME (84-335): 3.06e-52: 176: 10.63
+	Dm
		1095562 SNAP_DROME (3-289): 9.54e-100: 295: 32.40		Q86P91_DROME (1-334): 3.88e-51: 175: 18.64
+	Hs
		1205369 SNAB_HUMAN (3-289): 1.36e-101: 300: 33.80		STX12_HUMAN (78-328): 2.57e-47: 162: 17.06
+	Hs
		873559 SNAA_HUMAN (12-291): 5.14e-101: 299: 35.00		STX12_HUMAN (78-328): 2.57e-47: 162: 17.06
+	Hs
		178768 SNAB_HUMAN (3-289): 1.36e-101: 300: 33.80		STX7_HUMAN (95-320): 2.58e-45: 157: 18.50
+	Hs
		178454 SNAA_HUMAN (12-291): 5.14e-101: 299: 35.00		STX7_HUMAN (95-320): 2.58e-45: 157: 18.50
+	Hs
		1030185 SNAB_HUMAN (3-289): 1.36e-101: 300: 33.80		STX3_HUMAN (90-321): 5.45e-44: 154: 12.39
+	Hs
		873540 SNAA_HUMAN (12-291): 5.14e-101: 299: 35.00		STX3_HUMAN (90-321): 5.45e-44: 154: 12.39
+	Hs
		152174 SNAB_HUMAN (3-289): 1.36e-101: 300: 33.80		STX16_HUMAN (12-321): 7e-43: 152: 15.84
+	Hs
		152142 SNAA_HUMAN (12-291): 5.14e-101: 299: 35.00		STX16_HUMAN (12-321): 7e-43: 152: 15.84
+	Dm
		1095561 SNAP_DROME (3-289): 9.54e-100: 295: 32.40		Q7K0X9_DROME (89-339): 1.96e-15: 77.3: 16.98