HitPredict

Interactor 1: RAD23 (P32628)
UV excision repair protein RAD23
Gene: RAD23

Interactor 2: RPN1 (P38764)
26S proteasome regulatory subunit RPN1 (HMG-CoA reductase degradation protein 2) (Proteasome non-ATPase subunit 1)
Gene: RPN1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.989

Property	Details
Experiments	12200120, 11595789, 26912900, 12198498, 18511945, 10688190, 17082762, 18757749, 34364874, 33617881, 21627799, 22318722, 15121879, 16554755, 27396824, 37968396, 20059542, 16401726, 16429126
Identification Methods	cross-linking study, two hybrid, pull down, isothermal titration calorimetry, filter binding, nuclear magnetic resonance, affinity chromatography technology, far western blotting, x-ray crystallography, two hybrid array and 1 others more... tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PC_rep~ubiquitin
Common GO terms	GO:0005737 - cytoplasm GO:0030674 - protein-macromolecule adaptor activity GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 398 Sc			1 993
+	Rn
		1116239 RD23B_RAT (2-398): 7.78e-92: 284: 27.50		PSMD2_RAT (2-989): 0: 1013: 34.70
+	Hs
		872262 RD23B_HUMAN (2-398): 5.1e-90: 279: 27.50		PSMD2_HUMAN (2-989): 0: 1010: 34.61
+	Hs
		872151 RD23A_HUMAN (2-398): 3.37e-87: 270: 28.09		PSMD2_HUMAN (2-989): 0: 1010: 34.61
+	Hs
		1027821 UBQL1_HUMAN (1-373): 1.05e-58: 202: 12.53		PSMD2_HUMAN (2-989): 0: 1010: 34.61
+	Hs
		1027815 UBQL2_HUMAN (1-373): 8.68e-55: 192: 12.65		PSMD2_HUMAN (2-989): 0: 1010: 34.61
+	At
		1195577 RD23C_ARATH (2-398): 8.2e-89: 276: 25.62		PSD2A_ARATH (38-992): 0: 925: 33.61
+	Sc
		753873 DSK2_YEAST (2-282): 4.39e-39: 145: 17.09		RPN1_YEAST (1-993): 0: 1053: 100.00
+	Hs
		1027806 UBQL4_HUMAN (2-373): 1.16e-52: 186: 13.76		PSMD2_HUMAN (2-989): 0: 1010: 34.61
+	Hs
		923974 RS27A_HUMAN (2-89): 1.27e-38: 137: 22.73		PSMD2_HUMAN (2-989): 0: 1010: 34.61
+	Sp
		251964 RHP23_SCHPO (2-398): 4.18e-81: 255: 33.25		RPN1_SCHPO (5-988): 0: 871: 37.71
+	Hs
		872303 RD23B_HUMAN (2-398): 5.1e-90: 279: 27.50		PSMD1_HUMAN (52-925): 0: 709: 13.42
+	Rn
		292215 RD23B_RAT (2-398): 7.78e-92: 284: 27.50		PSMD1_RAT (52-925): 0: 699: 13.20
+	Hs
		872202 RD23A_HUMAN (2-398): 3.37e-87: 270: 28.09		PSMD1_HUMAN (52-925): 0: 709: 13.42
+	Dm
		1362832 Q9VCD5_DROME (2-398): 1.55e-52: 178: 20.55		Q9VW54_DROME (1-989): 0: 738: 33.30
+	Hs
		1303954 UBQL1_HUMAN (1-373): 1.05e-58: 202: 12.53		PSMD1_HUMAN (52-925): 0: 709: 13.42
+	Dm
		1374998 Q9VWD9_DROME (2-374): 1.81e-47: 171: 13.38		Q9VW54_DROME (1-989): 0: 738: 33.30
+	Hs
		1303948 UBQL2_HUMAN (1-373): 8.68e-55: 192: 12.65		PSMD1_HUMAN (52-925): 0: 709: 13.42
+	Hs
		1303937 UBQL4_HUMAN (2-373): 1.16e-52: 186: 13.76		PSMD1_HUMAN (52-925): 0: 709: 13.42
+	Sc
		693266 RAD23_YEAST (1-398): 8.4e-101: 306: 100.00		RPN2_YEAST (52-815): 2.95e-177: 542: 15.54
+	Dm
		1359018 Q9VWD9_DROME (2-374): 1.81e-47: 171: 13.38		PSMD1_DROME (52-925): 0: 664: 13.63