HitPredict

Interactor 1: BRR2 (P32639)
Pre-mRNA-splicing helicase BRR2 (EC 3.6.4.13) (Protein Snu246)
Gene: BRR2

Interactor 2: SYF1 (Q04048)
Pre-mRNA-splicing factor SYF1 (PRP19-associated complex protein 90) (Synthetic lethal with CDC40 protein 1)
Gene: SYF1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	25670679, 16429126, 37968396, 21576257
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2163 Sc			1 859
+	Hs
		271991 U520_HUMAN (16-2163): 0: 1597: 38.84		PRP6_HUMAN (459-856): 1.36e-23: 109: 12.94
+	At
		98519 DEXHC_ARATH (14-2163): 0: 1552: 38.06		F4JZX8_ARATH (494-848): 9.54e-24: 109: 13.81
+	Dm
		54175 U520_DROME (14-2162): 0: 1550: 38.66		SYF1_DROME (67-572): 9.84e-18: 90.4: 9.65
+	Sc
		586385 BRR2_YEAST (1-2163): 0: 1534: 100.00		PRP6_YEAST (157-799): 5.81e-22: 103: 12.19
+	At
		1338521 DEXHC_ARATH (14-2163): 0: 1552: 38.06		Q9LKU3_ARATH (391-859): 4.23e-12: 72.3: 10.30
+	Sc
		697276 BRR2_YEAST (1-2163): 0: 1534: 100.00		CLF1_YEAST (4-377): 2.18e-12: 72.7: 11.71
+	Sp
		1015544 BRR2_SCHPO (5-2162): 0: 1396: 41.00		PRP1_SCHPO (202-841): 1.62e-17: 89.7: 8.50
+	Sp
		1350845 BRR2_SCHPO (5-2162): 0: 1396: 41.00		SYF1_SCHPO (393-839): 1.1e-14: 80.4: 12.66
+	Sp
		953585 BRR2_SCHPO (5-2162): 0: 1396: 41.00		CLF1_SCHPO (645-858): 1.89e-14: 79.7: 14.82
+	Sp
		142997 YE02_SCHPO (377-925): 4.47e-87: 311: 21.59		RNA14_SCHPO (306-820): 2.78e-35: 145: 10.56
+	Hs
		300219 DDX17_HUMAN (1345-1753): 1.1e-96: 332: 11.35		PRP6_HUMAN (459-856): 1.36e-23: 109: 12.94
+	Sc
		810915 MTR4_YEAST (364-927): 1.48e-92: 329: 20.07		RRP5_YEAST (572-839): 8.35e-22: 104: 15.96
+	Sp
		143054 YE02_SCHPO (377-925): 4.47e-87: 311: 21.59		PRP39_SCHPO (215-733): 7.3e-22: 103: 11.05
+	Hs
		300254 DDX23_HUMAN (1275-1768): 3.27e-82: 292: 13.30		PRP6_HUMAN (459-856): 1.36e-23: 109: 12.94
+	Sp
		143158 YE02_SCHPO (377-925): 4.47e-87: 311: 21.59		PRP1_SCHPO (202-841): 1.62e-17: 89.7: 8.50
+	Hs
		1058019 DDX23_HUMAN (1275-1768): 3.27e-82: 292: 13.30		RRP5_HUMAN (76-379): 2.3e-22: 105: 9.12
+	Sp
		143198 YE02_SCHPO (377-925): 4.47e-87: 311: 21.59		SYF1_SCHPO (393-839): 1.1e-14: 80.4: 12.66
+	Sp
		143121 YE02_SCHPO (377-925): 4.47e-87: 311: 21.59		CLF1_SCHPO (645-858): 1.89e-14: 79.7: 14.82
+	Sp
		143042 YE02_SCHPO (377-925): 4.47e-87: 311: 21.59		RRP5_SCHPO (413-741): 1.86e-11: 70.4: 10.00
+	Hs
		1160966 DDX23_HUMAN (1275-1768): 3.27e-82: 292: 13.30		CTR9_HUMAN (302-847): 4.99e-12: 71.9: 9.92