HitPredict

Interactor 1: BRR2 (P32639)
Pre-mRNA-splicing helicase BRR2 (EC 3.6.4.13) (Protein Snu246)
Gene: BRR2

Interactor 2: CLF1 (Q12309)
Pre-mRNA-splicing factor CLF1 (Crooked neck-like factor 1) (PRP19-associated complex protein 77) (Synthetic lethal with CDC40 protein 3)
Gene: CLF1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	16429126, 12509417, 25670679, 37968396
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2163 Sc			1 687
+	At
		98519 DEXHC_ARATH (14-2163): 0: 1552: 38.06		F4JZX8_ARATH (5-686): 6.2e-114: 360: 33.24
+	Dm
		54175 U520_DROME (14-2162): 0: 1550: 38.66		SYF1_DROME (3-674): 1.7e-77: 267: 14.23
+	Sp
		953585 BRR2_SCHPO (5-2162): 0: 1396: 41.00		CLF1_SCHPO (5-686): 5.61e-121: 377: 39.21
+	Sc
		697256 BRR2_YEAST (1-2163): 0: 1534: 100.00		SYF1_YEAST (54-674): 1.42e-57: 211: 11.97
+	Hs
		271991 U520_HUMAN (16-2163): 0: 1597: 38.84		PRP6_HUMAN (449-672): 5e-10: 64.9: 11.89
+	At
		1338521 DEXHC_ARATH (14-2163): 0: 1552: 38.06		Q9LKU3_ARATH (13-580): 5.24e-22: 103: 11.47
+	Sp
		1350845 BRR2_SCHPO (5-2162): 0: 1396: 41.00		SYF1_SCHPO (13-674): 9.29e-65: 230: 13.74
+	Sc
		586385 BRR2_YEAST (1-2163): 0: 1534: 100.00		PRP6_YEAST (28-198): 6.71e-10: 64.6: 13.30
+	Sp
		1015544 BRR2_SCHPO (5-2162): 0: 1396: 41.00		PRP1_SCHPO (1-392): 2.83e-20: 98.1: 13.22
+	Sp
		143121 YE02_SCHPO (377-925): 4.47e-87: 311: 21.59		CLF1_SCHPO (5-686): 5.61e-121: 377: 39.21
+	Sp
		143198 YE02_SCHPO (377-925): 4.47e-87: 311: 21.59		SYF1_SCHPO (13-674): 9.29e-65: 230: 13.74
+	Hs
		175083 DDX17_HUMAN (1345-1753): 1.1e-96: 332: 11.35		OGT1_HUMAN (3-340): 4.64e-40: 160: 14.12
+	Hs
		174608 DDX5_HUMAN (1344-1752): 6.23e-93: 317: 11.35		OGT1_HUMAN (3-340): 4.64e-40: 160: 14.12
+	Sp
		142997 YE02_SCHPO (377-925): 4.47e-87: 311: 21.59		RNA14_SCHPO (126-655): 6.92e-34: 140: 14.78
+	Sc
		810915 MTR4_YEAST (364-927): 1.48e-92: 329: 20.07		RRP5_YEAST (335-642): 1.55e-24: 111: 14.56
+	Sp
		143054 YE02_SCHPO (377-925): 4.47e-87: 311: 21.59		PRP39_SCHPO (267-653): 3.13e-23: 106: 14.52
+	Sp
		143158 YE02_SCHPO (377-925): 4.47e-87: 311: 21.59		PRP1_SCHPO (1-392): 2.83e-20: 98.1: 13.22
+	Hs
		300219 DDX17_HUMAN (1345-1753): 1.1e-96: 332: 11.35		PRP6_HUMAN (449-672): 5e-10: 64.9: 11.89
+	Sp
		143042 YE02_SCHPO (377-925): 4.47e-87: 311: 21.59		RRP5_SCHPO (75-346): 9.42e-10: 64.4: 16.19
+	Hs
		300254 DDX23_HUMAN (1275-1768): 3.27e-82: 292: 13.30		PRP6_HUMAN (449-672): 5e-10: 64.9: 11.89