HitPredict

Interactor 1: RAD24 (P32641)
Checkpoint protein RAD24
Gene: RAD24

Interactor 2: RFC3 (P38629)
Replication factor C subunit 3 (Replication factor C3) (Activator 1 40 kDa subunit)
Gene: RFC3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.752

Property	Details
Experiments	11805837, 10660302, 10913172, 12604797, 15014082, 31182279, 35314830, 37968396
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology, pull down, biochemical, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000077 - DNA damage checkpoint signaling GO:0003689 - DNA clamp loader activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0006281 - DNA repair and 1 others more... GO:0031389 - Rad17 RFC-like complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 659 Sc			1 340
+	Sc
		697297 RAD24_YEAST (1-659): 0: 796: 100.00		RFC2_YEAST (1-329): 5.33e-75: 236: 32.26
+	Sc
		697296 RAD24_YEAST (1-659): 0: 796: 100.00		RFC4_YEAST (12-333): 2.2e-72: 229: 34.06
+	Sc
		697288 RAD24_YEAST (1-659): 0: 796: 100.00		RFC5_YEAST (14-332): 9.6e-71: 225: 21.97
+	Sc
		751260 RFC1_YEAST (21-552): 2.09e-75: 260: 15.43		RFC3_YEAST (1-340): 2.34e-95: 288: 100.00
+	Hs
		722179 RFC1_HUMAN (36-492): 1.99e-72: 255: 12.75		RFC5_HUMAN (8-338): 3.34e-86: 264: 49.40
+	Hs
		777901 CTF18_HUMAN (8-465): 4.34e-73: 255: 11.17		RFC5_HUMAN (8-338): 3.34e-86: 264: 49.40
+	Hs
		721936 RFC4_HUMAN (30-407): 3.57e-77: 252: 16.06		RFC5_HUMAN (8-338): 3.34e-86: 264: 49.40
+	Hs
		721934 RFC1_HUMAN (36-492): 1.99e-72: 255: 12.75		RFC4_HUMAN (3-332): 3.98e-83: 258: 34.62
+	Hs
		722015 CTF18_HUMAN (8-465): 4.34e-73: 255: 11.17		RFC4_HUMAN (3-332): 3.98e-83: 258: 34.62
+	Hs
		722068 RFC1_HUMAN (36-492): 1.99e-72: 255: 12.75		RFC2_HUMAN (13-329): 5.29e-79: 246: 34.59
+	Hs
		722134 CTF18_HUMAN (8-465): 4.34e-73: 255: 11.17		RFC2_HUMAN (13-329): 5.29e-79: 246: 34.59
+	Hs
		721933 RFC4_HUMAN (30-407): 3.57e-77: 252: 16.06		RFC2_HUMAN (13-329): 5.29e-79: 246: 34.59
+	Sc
		751312 RFC1_YEAST (21-552): 2.09e-75: 260: 15.43		RFC2_YEAST (1-329): 5.33e-75: 236: 32.26
+	Ce
		1090164 Q18841_CAEEL (49-493): 1.94e-80: 274: 15.24		Q18547_CAEEL (14-328): 7.93e-69: 221: 23.34
+	Sc
		751310 RFC1_YEAST (21-552): 2.09e-75: 260: 15.43		RFC4_YEAST (12-333): 2.2e-72: 229: 34.06
+	Sc
		747101 RFC1_YEAST (21-552): 2.09e-75: 260: 15.43		RFC5_YEAST (14-332): 9.6e-71: 225: 21.97
+	Ce
		858450 Q18841_CAEEL (49-493): 1.94e-80: 274: 15.24		RFC4_CAEEL (6-331): 1.96e-63: 206: 34.34
+	Hs
		722180 RFC1_HUMAN (36-492): 1.99e-72: 255: 12.75		RFC3_HUMAN (14-333): 1.78e-60: 199: 23.78
+	Hs
		778019 CTF18_HUMAN (8-465): 4.34e-73: 255: 11.17		RFC3_HUMAN (14-333): 1.78e-60: 199: 23.78
+	Hs
		721937 RFC4_HUMAN (30-407): 3.57e-77: 252: 16.06		RFC3_HUMAN (14-333): 1.78e-60: 199: 23.78