HitPredict

Interactor 1: B1ASP2 (B1ASP2)
Tyrosine-protein kinase (EC 2.7.10.2)
Gene: Jak1

Interactor 2: Q99K94 (Q99K94)
Signal transducer and activator of transcription
Gene: Stat1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	32814877
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_F1~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005634 - nucleus GO:0007259 - cell surface receptor signaling pathway via JAK-STAT GO:0060337 - type I interferon-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1153 Mm			1 712
+	Hs
		616755 JAK1_HUMAN (1-1153): 0: 1080: 94.46		STAT1_HUMAN (1-712): 0: 932: 93.68
+	Hs
		616754 JAK1_HUMAN (1-1153): 0: 1080: 94.46		STAT3_HUMAN (1-710): 0: 858: 53.70
+	Mm
		69811 B1ASP2_MOUSE (1-1153): 0: 1115: 100.00		STA5A_MOUSE (1-710): 0: 743: 29.44
+	Hs
		616771 JAK1_HUMAN (1-1153): 0: 1080: 94.46		STAT2_HUMAN (1-710): 0: 765: 43.93
+	Hs
		669138 TYK2_HUMAN (35-1153): 0: 908: 44.62		STAT1_HUMAN (1-712): 0: 932: 93.68
+	Rn
		1144008 JAK2_RAT (27-1152): 0: 875: 41.68		Q6P6Q7_RAT (1-712): 0: 963: 98.74
+	Hs
		616768 JAK1_HUMAN (1-1153): 0: 1080: 94.46		STA5B_HUMAN (1-710): 0: 747: 30.47
+	Hs
		616757 JAK1_HUMAN (1-1153): 0: 1080: 94.46		STA5A_HUMAN (1-710): 0: 736: 29.70
+	Hs
		238378 JAK2_HUMAN (21-1152): 0: 874: 41.72		STAT1_HUMAN (1-712): 0: 932: 93.68
+	Hs
		238377 JAK2_HUMAN (21-1152): 0: 874: 41.72		STAT3_HUMAN (1-710): 0: 858: 53.70
+	Mm
		786536 JAK2_MOUSE (27-1152): 0: 868: 41.59		STAT3_MOUSE (1-710): 0: 859: 53.70
+	Hs
		616756 JAK1_HUMAN (1-1153): 0: 1080: 94.46		STAT6_HUMAN (1-711): 0: 627: 25.75
+	Hs
		669149 TYK2_HUMAN (35-1153): 0: 908: 44.62		STAT2_HUMAN (1-710): 0: 765: 43.93
+	Hs
		669147 TYK2_HUMAN (35-1153): 0: 908: 44.62		STA5B_HUMAN (1-710): 0: 747: 30.47
+	Hs
		669139 TYK2_HUMAN (35-1153): 0: 908: 44.62		STA5A_HUMAN (1-710): 0: 736: 29.70
+	Hs
		238387 JAK2_HUMAN (21-1152): 0: 874: 41.72		STA5B_HUMAN (1-710): 0: 747: 30.47
+	Mm
		786666 JAK2_MOUSE (27-1152): 0: 868: 41.59		STA5B_MOUSE (1-710): 0: 747: 30.20
+	Mm
		786654 JAK2_MOUSE (27-1152): 0: 868: 41.59		STA5A_MOUSE (1-710): 0: 743: 29.44
+	Rn
		1144005 JAK2_RAT (27-1152): 0: 875: 41.68		STA5A_RAT (1-710): 0: 735: 29.30
+	Hs
		238379 JAK2_HUMAN (21-1152): 0: 874: 41.72		STA5A_HUMAN (1-710): 0: 736: 29.70