HitPredict

Interactor 1: TIM12 (P32830)
Mitochondrial import inner membrane translocase subunit TIM12 (Mitochondrial regulator of splicing 5)
Gene: TIM12

Interactor 2: TIM10 (P87108)
Mitochondrial import inner membrane translocase subunit TIM10 (Mitochondrial intermembrane protein MRS11)
Gene: TIM10

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.942

Property	Details
Experiments	9236772, 9430585, 9889188, 9495346, 32591483, 23267104
Identification Methods	two hybrid, affinity chromatography technology, coimmunoprecipitation, anti bait coimmunoprecipitation, miniaturized immunoprecipitation
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	zf-Tim10_DDP~zf-Tim10_DDP
Common GO terms	GO:0005739 - mitochondrion GO:0005743 - mitochondrial inner membrane GO:0042719 - mitochondrial intermembrane space protein transporter complex GO:0042721 - TIM22 mitochondrial import inner membrane insertion complex GO:0045039 - protein insertion into mitochondrial inner membrane and 1 others more... GO:0046872 - metal ion binding
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 109 Sc			1 93
+	Sc
		698614 TIM12_YEAST (1-109): 3.37e-55: 168: 100.00		TIM12_YEAST (1-84): 7.94e-30: 104: 35.29
+	Sc
		953319 TIM10_YEAST (1-85): 1.94e-33: 113: 35.29		TIM10_YEAST (1-93): 1.73e-42: 135: 100.00