HitPredict

Interactor 1: TIM12 (P32830)
Mitochondrial import inner membrane translocase subunit TIM12 (Mitochondrial regulator of splicing 5)
Gene: TIM12

Interactor 2: TIM22 (Q12328)
Mitochondrial import inner membrane translocase subunit TIM22
Gene: TIM22

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.943

Property	Details
Experiments	9430585, 11509656, 10648604, 9495346, 32918038, 32591483
Identification Methods	affinity chromatography technology, coimmunoprecipitation, anti bait coimmunoprecipitation, biochemical
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Tim17~zf-Tim10_DDP
Common GO terms	GO:0005739 - mitochondrion GO:0005743 - mitochondrial inner membrane GO:0042721 - TIM22 mitochondrial import inner membrane insertion complex GO:0045039 - protein insertion into mitochondrial inner membrane
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 109 Sc			1 207
+	Sc
		953324 TIM10_YEAST (1-85): 1.94e-33: 113: 35.29		TIM22_YEAST (1-207): 1.31e-79: 238: 100.00
+	Hs
		905498 TIM10_HUMAN (21-97): 6.61e-30: 104: 27.27		TIM22_HUMAN (23-194): 1.1e-45: 151: 31.98