HitPredict

Interactor 1: SCN2A (B1AWN6)
Sodium channel protein type 2 subunit alpha (Voltage-gated sodium channel subunit alpha Nav1.2)
Gene: SCN2A

Interactor 2: NEDD4 (P46935)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	15123669
Identification Methods	far western blotting
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0006814 - sodium ion transport GO:0016020 - membrane GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2006 Mm			1 887
+	Mm
		808358 SCN9A_MOUSE (4-2003): 0: 1937: 76.12		NEDD4_MOUSE (1-887): 0: 935: 100.00
+	Mm
		808381 SCN8A_MOUSE (1-2005): 0: 1866: 73.30		NEDD4_MOUSE (1-887): 0: 935: 100.00
+	Mm
		69865 SCN2A_MOUSE (1-2006): 0: 2118: 100.00		E9PXB7_MOUSE (172-887): 0: 665: 56.84
+	Mm
		808378 SCN5A_MOUSE (3-1999): 0: 1798: 61.73		NEDD4_MOUSE (1-887): 0: 935: 100.00
+	Hs
		723839 SCN1A_HUMAN (1-1999): 0: 1983: 85.45		NEDD4_HUMAN (157-887): 0: 724: 78.95
+	Mm
		808363 SCNAA_MOUSE (8-2002): 0: 1745: 54.09		NEDD4_MOUSE (1-887): 0: 935: 100.00
+	Hs
		723851 SCN1A_HUMAN (1-1999): 0: 1983: 85.45		SMUF2_HUMAN (79-883): 0: 678: 34.20
+	Hs
		1079738 SCN9A_HUMAN (4-2006): 0: 1963: 76.30		SMUF2_HUMAN (79-883): 0: 678: 34.20
+	Mm
		93274 SCN9A_MOUSE (4-2003): 0: 1937: 76.12		E9PXB7_MOUSE (172-887): 0: 665: 56.84
+	Hs
		808322 SCN8A_HUMAN (1-2005): 0: 1858: 73.50		NEDD4_HUMAN (157-887): 0: 724: 78.95
+	Hs
		1055040 SCN5A_HUMAN (3-1999): 0: 1804: 61.66		NED4L_HUMAN (70-887): 0: 777: 55.91
+	Mm
		93284 SCN8A_MOUSE (1-2005): 0: 1866: 73.30		E9PXB7_MOUSE (172-887): 0: 665: 56.84
+	Hs
		808128 SCN5A_HUMAN (3-1999): 0: 1804: 61.66		NEDD4_HUMAN (157-887): 0: 724: 78.95
+	Hs
		1055045 SCN5A_HUMAN (3-1999): 0: 1804: 61.66		SMUF2_HUMAN (79-883): 0: 678: 34.20
+	Hs
		125457 SCN5A_HUMAN (3-1999): 0: 1804: 61.66		WWP2_HUMAN (75-884): 0: 675: 33.18
+	Mm
		93283 SCN5A_MOUSE (3-1999): 0: 1798: 61.73		E9PXB7_MOUSE (172-887): 0: 665: 56.84
+	Mm
		93276 SCNAA_MOUSE (8-2002): 0: 1745: 54.09		E9PXB7_MOUSE (172-887): 0: 665: 56.84
+	Mm
		808349 Q3UF73_MOUSE (1-202): 4.79e-111: 353: 85.64		NEDD4_MOUSE (1-887): 0: 935: 100.00
+	Mm
		93270 Q3UF73_MOUSE (1-202): 4.79e-111: 353: 85.64		E9PXB7_MOUSE (172-887): 0: 665: 56.84
+	Hs
		808340 SCNAA_HUMAN (1525-2006): 9.41e-39: 161: 17.14		NEDD4_HUMAN (157-887): 0: 724: 78.95