HitPredict

Interactor 1: GSP1 (P32835)
GTP-binding nuclear protein GSP1/CNR1 (Chromosome stability protein 17) (GTPase Ran homolog) (Genetic suppressor of PRP20-1)
Gene: GSP1

Interactor 2: CSE1 (P33307)
Importin alpha re-exporter (Chromosome segregation protein CSE1)
Gene: CSE1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.974

Property	Details
Experiments	10617640, 9744791, 9214382, 9774694, 12578832, 15679097, 10825193, 12543930, 18719252
Identification Methods	affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	CAS_CSE1~Ras, Cse1~Ras, IBN_N~Ras
Common GO terms	GO:0005829 - cytosol GO:0006606 - protein import into nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 219 Sc			1 960
+	Hs
		874484 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		XPO2_HUMAN (2-959): 0: 690: 34.67
+	Sc
		698999 GSP2_YEAST (1-219): 9.33e-78: 234: 96.82		CSE1_YEAST (1-960): 0: 653: 100.00
+	Sp
		142272 SPI1_SCHPO (5-219): 6.33e-77: 232: 88.37		CSE1_SCHPO (4-956): 0: 558: 39.36
+	Hs
		312234 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		IPO7_HUMAN (3-920): 3.51e-169: 523: 15.27
+	Hs
		178143 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		IPO8_HUMAN (3-906): 5.3e-164: 509: 16.06
+	Dm
		1373317 RANL_DROME (13-219): 2.1e-90: 266: 59.42		Q9VRV8_DROME (4-890): 3.92e-139: 440: 12.54
+	At
		784992 RAN1_ARATH (1-216): 6.84e-94: 275: 75.58		IMB1_ARATH (6-901): 1.15e-134: 427: 10.83
+	At
		784999 RAN2_ARATH (1-216): 1.74e-88: 261: 75.58		IMB1_ARATH (6-901): 1.15e-134: 427: 10.83
+	At
		1210454 RAN3_ARATH (1-219): 5.37e-84: 250: 74.55		IMB1_ARATH (6-901): 1.15e-134: 427: 10.83
+	Hs
		919198 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		TNPO1_HUMAN (13-890): 4.9e-139: 440: 13.42
+	Hs
		155560 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		TNPO2_HUMAN (13-896): 9.91e-138: 436: 14.14
+	Sc
		698861 GSP1_YEAST (1-219): 1.49e-79: 239: 100.00		NMD5_YEAST (3-886): 1.82e-130: 421: 15.34
+	At
		784988 RAN1_ARATH (1-216): 6.84e-94: 275: 75.58		TNPO1_ARATH (4-877): 3.41e-118: 384: 11.90
+	Hs
		127238 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		IPO5_HUMAN (14-892): 2.24e-125: 408: 12.00
+	Hs
		919077 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		IMB1_HUMAN (6-836): 8.41e-122: 393: 11.94
+	Hs
		919222 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		IPO9_HUMAN (2-895): 7.5e-120: 392: 13.26
+	Sc
		698930 GSP1_YEAST (1-219): 1.49e-79: 239: 100.00		SXM1_YEAST (1-958): 2.84e-114: 375: 17.61
+	Sc
		698917 GSP1_YEAST (1-219): 1.49e-79: 239: 100.00		KA120_YEAST (7-953): 4.58e-111: 369: 15.53
+	Sc
		699016 GSP2_YEAST (1-219): 9.33e-78: 234: 96.82		KA120_YEAST (7-953): 4.58e-111: 369: 15.53
+	Sc
		698878 GSP1_YEAST (1-219): 1.49e-79: 239: 100.00		IMB5_YEAST (3-922): 1.45e-103: 348: 15.42