HitPredict

Interactor 1: GSP1 (P32835)
GTP-binding nuclear protein GSP1/CNR1 (Chromosome stability protein 17) (GTPase Ran homolog) (Genetic suppressor of PRP20-1)
Gene: GSP1

Interactor 2: XPOT (P33418)
Exportin-T (Exportin(tRNA)) (Karyopherin-beta) (tRNA exportin)
Gene: LOS1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.905

Property	Details
Experiments	9774653, 10617640, 25838545, 17634288
Identification Methods	two hybrid, biochemical, affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Exportin-T~Ras, Ras~Xpo1
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 219 Sc			1 1100
+	Sc
		699000 GSP2_YEAST (1-219): 9.33e-78: 234: 96.82		XPOT_YEAST (1-1100): 0: 757: 100.00
+	Hs
		162599 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		XPO1_HUMAN (2-1099): 0: 665: 14.48
+	Sc
		675912 GSP1_YEAST (1-219): 1.49e-79: 239: 100.00		XPO1_YEAST (2-1099): 0: 576: 12.15
+	Hs
		207921 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		XPOT_HUMAN (6-1095): 2.04e-166: 518: 18.18
+	Sp
		292805 SPI1_SCHPO (5-219): 6.33e-77: 232: 88.37		XPOT_SCHPO (3-1099): 4.68e-155: 488: 23.51
+	Hs
		914368 RB11A_HUMAN (1-207): 4.63e-79: 237: 26.17		XPO5_HUMAN (1-946): 1.33e-145: 469: 11.53
+	Hs
		919273 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		XPO5_HUMAN (1-946): 1.33e-145: 469: 11.53
+	At
		784987 RAN1_ARATH (1-216): 6.84e-94: 275: 75.58		MOS14_ARATH (3-905): 1.57e-119: 393: 11.52
+	Hs
		919228 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		XPO6_HUMAN (2-1053): 3.48e-122: 404: 11.62
+	Hs
		207913 RAB9A_HUMAN (8-170): 8.21e-28: 106: 31.77		XPOT_HUMAN (6-1095): 2.04e-166: 518: 18.18
+	Sc
		698996 GSP1_YEAST (1-219): 1.49e-79: 239: 100.00		MTR10_YEAST (2-965): 5.64e-110: 367: 13.47
+	Hs
		297168 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		IPO13_HUMAN (2-925): 1.93e-111: 371: 13.29
+	Sc
		699022 GSP2_YEAST (1-219): 9.33e-78: 234: 96.82		MTR10_YEAST (2-965): 5.64e-110: 367: 13.47
+	Sc
		697582 GSP1_YEAST (1-219): 1.49e-79: 239: 100.00		KA122_YEAST (2-927): 3.8e-103: 351: 11.95
+	Sc
		697583 GSP2_YEAST (1-219): 9.33e-78: 234: 96.82		KA122_YEAST (2-927): 3.8e-103: 351: 11.95
+	Sc
		698877 GSP1_YEAST (1-219): 1.49e-79: 239: 100.00		MSN5_YEAST (4-480): 4.8e-53: 205: 10.08
+	Hs
		919301 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		XPO7_HUMAN (13-1076): 1.38e-20: 100: 10.87