HitPredict

Interactor 1: GSP1 (P32835)
GTP-binding nuclear protein GSP1/CNR1 (Chromosome stability protein 17) (GTPase Ran homolog) (Genetic suppressor of PRP20-1)
Gene: GSP1

Interactor 2: IMB5 (P53067)
Importin subunit beta-5 (114 kDa karyopherin) (Karyopherin subunit beta-5) (Karyopherin-114)
Gene: KAP114

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.947

Property	Details
Experiments	15679097, 17485461, 32484313, 21329658, 37450495, 22562154
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	IBN_N~Ras
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006606 - protein import into nucleus
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 219 Sc			1 1004
+	Hs
		312234 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		IPO7_HUMAN (1-1002): 0: 569: 13.62
+	Hs
		178143 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		IPO8_HUMAN (1-1002): 1.61e-179: 551: 12.55
+	Hs
		874484 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		XPO2_HUMAN (3-949): 5.99e-165: 511: 11.44
+	At
		784992 RAN1_ARATH (1-216): 6.84e-94: 275: 75.58		IMB1_ARATH (1-831): 1.03e-144: 455: 13.05
+	Hs
		919222 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		IPO9_HUMAN (3-1002): 1.48e-159: 499: 17.62
+	At
		784999 RAN2_ARATH (1-216): 1.74e-88: 261: 75.58		IMB1_ARATH (1-831): 1.03e-144: 455: 13.05
+	At
		1210454 RAN3_ARATH (1-219): 5.37e-84: 250: 74.55		IMB1_ARATH (1-831): 1.03e-144: 455: 13.05
+	Dm
		1373317 RANL_DROME (13-219): 2.1e-90: 266: 59.42		Q9VRV8_DROME (2-842): 1.16e-132: 424: 10.46
+	Hs
		919077 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		IMB1_HUMAN (1-876): 4.04e-142: 448: 10.93
+	Hs
		919198 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		TNPO1_HUMAN (8-841): 4.95e-133: 425: 10.71
+	Hs
		155560 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		TNPO2_HUMAN (8-841): 2.41e-129: 415: 10.72
+	Sc
		698750 GSP1_YEAST (1-219): 1.49e-79: 239: 100.00		CSE1_YEAST (10-898): 1.81e-121: 396: 14.44
+	Sp
		142272 SPI1_SCHPO (5-219): 6.33e-77: 232: 88.37		CSE1_SCHPO (2-912): 7.61e-123: 400: 14.76
+	Sc
		698999 GSP2_YEAST (1-219): 9.33e-78: 234: 96.82		CSE1_YEAST (10-898): 1.81e-121: 396: 14.44
+	Hs
		919299 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		IPO11_HUMAN (3-812): 8.03e-118: 386: 15.12
+	Sc
		698930 GSP1_YEAST (1-219): 1.49e-79: 239: 100.00		SXM1_YEAST (3-938): 7.24e-40: 162: 12.91
+	Sc
		698861 GSP1_YEAST (1-219): 1.49e-79: 239: 100.00		NMD5_YEAST (1-830): 3.08e-39: 160: 13.64
+	Sc
		698917 GSP1_YEAST (1-219): 1.49e-79: 239: 100.00		KA120_YEAST (1-837): 2.87e-28: 125: 12.22
+	Sc
		699016 GSP2_YEAST (1-219): 9.33e-78: 234: 96.82		KA120_YEAST (1-837): 2.87e-28: 125: 12.22