HitPredict

Interactor 1: GSP1 (P32835)
GTP-binding nuclear protein GSP1/CNR1 (Chromosome stability protein 17) (GTPase Ran homolog) (Genetic suppressor of PRP20-1)
Gene: GSP1

Interactor 2: MTR10 (Q99189)
mRNA transport regulator MTR10
Gene: MTR10

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.911

Property	Details
Experiments	9545233, 9412460, 18719252, 21329658
Identification Methods	affinity chromatography technology, far western blotting, pull down, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	IBN_N~Ras, Ras~Xpo1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006606 - protein import into nucleus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 219 Sc			1 972
+	Sc
		699022 GSP2_YEAST (1-219): 9.33e-78: 234: 96.82		MTR10_YEAST (1-972): 0: 633: 100.00
+	At
		784987 RAN1_ARATH (1-216): 6.84e-94: 275: 75.58		MOS14_ARATH (6-964): 1.58e-147: 464: 18.14
+	Hs
		162599 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		XPO1_HUMAN (2-959): 3.01e-161: 503: 12.60
+	Sc
		675912 GSP1_YEAST (1-219): 1.49e-79: 239: 100.00		XPO1_YEAST (2-969): 6.84e-139: 445: 13.57
+	Dm
		1373317 RANL_DROME (13-219): 2.1e-90: 266: 59.42		Q9VRV8_DROME (42-873): 3.26e-125: 403: 12.24
+	Hs
		919198 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		TNPO1_HUMAN (68-873): 5.04e-133: 424: 12.89
+	At
		784988 RAN1_ARATH (1-216): 6.84e-94: 275: 75.58		TNPO1_ARATH (77-904): 6.18e-112: 368: 11.14
+	Hs
		127238 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		IPO5_HUMAN (66-949): 1.35e-124: 407: 13.58
+	Hs
		297168 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		IPO13_HUMAN (3-963): 8.25e-126: 407: 17.96
+	Hs
		207921 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		XPOT_HUMAN (10-937): 1.19e-125: 406: 14.89
+	Hs
		155560 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		TNPO2_HUMAN (42-865): 1.06e-123: 399: 12.62
+	Hs
		914368 RB11A_HUMAN (1-207): 4.63e-79: 237: 26.17		XPO5_HUMAN (1-825): 5.84e-108: 364: 11.76
+	Sp
		292805 SPI1_SCHPO (5-219): 6.33e-77: 232: 88.37		XPOT_SCHPO (4-948): 1.27e-109: 364: 14.68
+	Hs
		919273 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		XPO5_HUMAN (1-825): 5.84e-108: 364: 11.76
+	Hs
		236414 RB11A_HUMAN (1-207): 4.63e-79: 237: 26.17		RNBP6_HUMAN (67-945): 4.67e-105: 354: 12.90
+	Hs
		207913 RAB9A_HUMAN (8-170): 8.21e-28: 106: 31.77		XPOT_HUMAN (10-937): 1.19e-125: 406: 14.89
+	Sc
		698755 GSP1_YEAST (1-219): 1.49e-79: 239: 100.00		XPOT_YEAST (6-770): 2.07e-26: 119: 11.76
+	Sc
		699000 GSP2_YEAST (1-219): 9.33e-78: 234: 96.82		XPOT_YEAST (6-770): 2.07e-26: 119: 11.76