HitPredict

Interactor 1: STX1A (P32851)
Syntaxin-1A (Neuron-specific antigen HPC-1) (Synaptotagmin-associated 35 kDa protein) (P35A)
Gene: STX1A

Interactor 2: VAMP2 (P63045)
Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2)
Gene: VAMP2

Species: Rattus norvegicus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 1.00 0.953

The method score is based on:

Property Details
Experiments 18385322, 21266332, 22411134, 21193638, 25581794, 8567678, 9341137
Identification Methods affinity chromatography technology, pull down, anti bait coimmunoprecipitation, two hybrid
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains SNARE~Synaptobrevin, Synaptobrevin~Syntaxin
Common GO terms GO:0000149 - SNARE binding
GO:0005484 - SNAP receptor activity
GO:0005886 - plasma membrane
GO:0008021 - synaptic vesicle
GO:0016020 - membrane
and 19 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 288
Rn

1 116
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024