HitPredict

Interactor 1: STX2 (P32856)
Syntaxin-2 (Epimorphin)
Gene: STX2

Interactor 2: STXB1 (P61764)
Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67)
Gene: STXBP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	24700782, 12773094, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNARE~Sec1, Sec1~Syntaxin
Common GO terms	GO:0000149 - SNARE binding GO:0005886 - plasma membrane GO:0006886 - intracellular protein transport GO:0032991 - protein-containing complex GO:0048787 - presynaptic active zone membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 288 Hs			1 594
+	Mm
		139543 STX1B_MOUSE (1-287): 6.03e-81: 247: 64.81		STXB1_MOUSE (1-594): 0: 680: 100.00
+	Rn
		898824 STX1B_RAT (1-287): 6.03e-81: 247: 64.81		STXB1_RAT (1-594): 0: 680: 100.00
+	Hs
		898829 STX1B_HUMAN (1-287): 6.03e-81: 247: 64.81		STXB1_HUMAN (1-594): 0: 680: 100.00
+	Mm
		139528 STX1A_MOUSE (1-287): 5.2e-78: 240: 65.63		STXB1_MOUSE (1-594): 0: 680: 100.00
+	Bt
		699167 STX1A_BOVIN (1-287): 1.23e-77: 239: 64.24		STXB1_BOVIN (1-594): 0: 680: 100.00
+	Rn
		699173 STX1A_RAT (1-287): 7.28e-78: 239: 65.28		STXB1_RAT (1-594): 0: 680: 100.00
+	Hs
		901790 STX1A_HUMAN (1-286): 4.14e-76: 235: 64.46		STXB1_HUMAN (1-594): 0: 680: 100.00
+	Hs
		699262 STX2_HUMAN (1-288): 5.69e-82: 250: 100.00		STXB2_HUMAN (1-593): 0: 658: 63.47
+	Rn
		838509 STX2_RAT (1-265): 4.77e-72: 225: 89.51		STXB1_RAT (1-594): 0: 680: 100.00
+	Mm
		192851 STX1A_MOUSE (1-287): 5.2e-78: 240: 65.63		STXB2_MOUSE (1-593): 0: 659: 62.80
+	Rn
		699178 STX1A_RAT (1-287): 7.28e-78: 239: 65.28		STXB2_RAT (1-593): 0: 647: 62.35
+	Hs
		901776 STX4_HUMAN (1-286): 1.23e-60: 196: 42.57		STXB1_HUMAN (1-594): 0: 680: 100.00
+	Rn
		838510 STX2_RAT (1-265): 4.77e-72: 225: 89.51		STXB2_RAT (1-593): 0: 647: 62.35
+	Dm
		991124 STX1A_DROME (2-282): 1.01e-72: 226: 60.56		ROP_DROME (4-589): 0: 623: 62.67
+	Hs
		119613 STX2_HUMAN (1-288): 5.69e-82: 250: 100.00		STXB3_HUMAN (1-593): 0: 584: 50.59
+	Ce
		183451 STX1A_CAEEL (2-282): 1.49e-72: 226: 54.77		UNC18_CAEEL (4-590): 0: 603: 58.11
+	Hs
		119633 STX4_HUMAN (1-286): 1.23e-60: 196: 42.57		STXB3_HUMAN (1-593): 0: 584: 50.59
+	Hs
		1017732 STX4_HUMAN (1-286): 1.23e-60: 196: 42.57		SCFD1_HUMAN (4-588): 8.01e-163: 481: 14.62
+	Dm
		1096639 STX1A_DROME (2-282): 1.01e-72: 226: 60.56		SLY1_DROME (5-586): 5.16e-142: 427: 13.77
+	Hs
		1017818 STX4_HUMAN (1-286): 1.23e-60: 196: 42.57		VPS45_HUMAN (12-582): 5.03e-154: 456: 17.81