HitPredict

Interactor 1: STX2 (P32856)
Syntaxin-2 (Epimorphin)
Gene: STX2

Interactor 2: VAMP8 (Q9BV40)
Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB)
Gene: VAMP8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	12828989, 29360461
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin, Synaptobrevin~Syntaxin
Common GO terms	GO:0005484 - SNAP receptor activity GO:0005886 - plasma membrane GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 288 Hs			1 100
+	Hs
		620262 STX1B_HUMAN (1-287): 6.03e-81: 247: 64.81		VAMP1_HUMAN (6-85): 1.02e-25: 93.8: 32.50
+	Hs
		699263 STX2_HUMAN (1-288): 5.69e-82: 250: 100.00		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99
+	Dm
		1098086 STX1A_DROME (2-282): 1.01e-72: 226: 60.56		Q7JYX5_DROME (1-100): 8.7e-32: 112: 32.00
+	Rn
		699183 STX1A_RAT (1-287): 7.28e-78: 239: 65.28		VAMP7_RAT (1-100): 5.53e-27: 99: 40.00
+	Hs
		699254 STX2_HUMAN (1-288): 5.69e-82: 250: 100.00		VAMP2_HUMAN (6-82): 2.47e-23: 88: 35.07
+	Rn
		699182 STX1A_RAT (1-287): 7.28e-78: 239: 65.28		VAMP1_RAT (6-85): 9.7e-27: 96.5: 33.75
+	Mm
		898816 STX1B_MOUSE (1-287): 6.03e-81: 247: 64.81		VAMP2_MOUSE (6-82): 2.47e-23: 88: 35.07
+	Hs
		898830 STX1B_HUMAN (1-287): 6.03e-81: 247: 64.81		VAMP2_HUMAN (6-82): 2.47e-23: 88: 35.07
+	Hs
		850569 STX1A_HUMAN (1-286): 4.14e-76: 235: 64.46		VAMP7_HUMAN (1-100): 1.25e-26: 99.2: 38.00
+	Dm
		577220 STX1A_DROME (2-282): 1.01e-72: 226: 60.56		SYB_DROME (5-95): 3.25e-30: 106: 27.47
+	Hs
		620271 STX1A_HUMAN (1-286): 4.14e-76: 235: 64.46		VAMP1_HUMAN (6-85): 1.02e-25: 93.8: 32.50
+	Hs
		261664 STX1A_HUMAN (1-286): 4.14e-76: 235: 64.46		VAMP4_HUMAN (7-80): 3.4e-25: 93.4: 29.73
+	Mm
		192845 STX1A_MOUSE (1-287): 5.2e-78: 240: 65.63		VAMP2_MOUSE (6-82): 2.47e-23: 88: 35.07
+	Rn
		699175 STX1A_RAT (1-287): 7.28e-78: 239: 65.28		VAMP2_RAT (6-82): 2.47e-23: 88: 35.07
+	Hs
		1079327 STX1A_HUMAN (1-286): 4.14e-76: 235: 64.46		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99
+	Hs
		1083981 STX1A_HUMAN (1-286): 4.14e-76: 235: 64.46		VAMP8_HUMAN (1-100): 2.94e-24: 89.6: 100.00
+	Rn
		699186 STX1A_RAT (1-287): 7.28e-78: 239: 65.28		VAMP8_RAT (3-76): 1.6e-22: 85.3: 94.60
+	Hs
		926213 STX1A_HUMAN (1-286): 4.14e-76: 235: 64.46		VAMP2_HUMAN (6-82): 2.47e-23: 88: 35.07
+	Ce
		137701 STX1A_CAEEL (2-282): 1.49e-72: 226: 54.77		SYB1_CAEEL (8-82): 3.98e-24: 89.6: 33.33
+	Hs
		261655 STX4_HUMAN (1-286): 1.23e-60: 196: 42.57		VAMP4_HUMAN (7-80): 3.4e-25: 93.4: 29.73