HitPredict

Interactor 1: SH3GH (B1V8A0)
Endophilin-A homolog (Endophilin-1 homolog) (Uncoordinated protein 57)
Gene: unc-57

Interactor 2: SYNJ (G5ECL2)
Synaptojanin (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase) (Uncoordinated protein 26)
Gene: unc-26

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	23549480
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008021 - synaptic vesicle GO:0016020 - membrane GO:0016191 - synaptic vesicle uncoating GO:0070266 - necroptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 381 Ce			1 1119
+	Dm
		1137151 SH3G3_DROME (1-380): 6.28e-73: 233: 44.88		Q5U0V7_DROME (3-1115): 0: 1044: 37.84
+	Dm
		993185 GRAP_DROME (325-374): 1.75e-18: 84.9: 46.00		Q5U0V7_DROME (3-1115): 0: 1044: 37.84
+	Dm
		112574 M9ND00_DROME (243-377): 5.83e-13: 72.7: 20.71		Q5U0V7_DROME (3-1115): 0: 1044: 37.84
+	Hs
		166042 GRB2_HUMAN (325-376): 4.64e-12: 66.8: 35.85		SYNJ2_HUMAN (3-1106): 0: 1040: 32.66
+	Hs
		968139 SPTN1_HUMAN (3-381): 7.14e-39: 150: 13.47		OCRL_HUMAN (482-919): 8.02e-120: 393: 29.67
+	Hs
		968134 MYO1E_HUMAN (252-377): 3.64e-25: 109: 33.33		OCRL_HUMAN (482-919): 8.02e-120: 393: 29.67
+	Mm
		1141165 GRB2_MOUSE (325-376): 5.06e-12: 66.8: 35.85		SHIP1_MOUSE (486-1116): 2.08e-132: 434: 17.63
+	Hs
		176424 GRB2_HUMAN (325-376): 4.64e-12: 66.8: 35.85		SHIP2_HUMAN (487-1103): 3.02e-130: 429: 19.55
+	Hs
		924485 GRB2_HUMAN (325-376): 4.64e-12: 66.8: 35.85		OCRL_HUMAN (482-919): 8.02e-120: 393: 29.67
+	Hs
		203248 SH3G1_HUMAN (1-380): 9.5e-80: 251: 44.76		SYNJ1_HUMAN (892-1118): 5.28e-09: 62.8: 10.44
+	Rn
		193638 SH3G1_RAT (1-380): 6.02e-78: 246: 45.03		SYNJ1_RAT (797-1110): 6.05e-10: 65.9: 7.89
+	Mm
		88460 SH3G3_MOUSE (1-380): 4.87e-78: 245: 43.98		D3Z656_MOUSE (871-1114): 2.6e-09: 64: 9.84
+	Rn
		192356 SH3G3_RAT (1-380): 6.34e-77: 243: 43.46		SYNJ1_RAT (797-1110): 6.05e-10: 65.9: 7.89
+	Rn
		192354 SH3G2_RAT (1-380): 1.27e-76: 242: 42.93		SYNJ1_RAT (797-1110): 6.05e-10: 65.9: 7.89
+	Hs
		203249 SH3G2_HUMAN (1-380): 2.02e-77: 244: 43.19		SYNJ1_HUMAN (892-1118): 5.28e-09: 62.8: 10.44
+	Mm
		88459 SH3G2_MOUSE (1-380): 9.84e-77: 242: 43.46		D3Z656_MOUSE (871-1114): 2.6e-09: 64: 9.84
+	Hs
		203262 PACN2_HUMAN (3-378): 9.03e-43: 157: 12.41		SYNJ1_HUMAN (892-1118): 5.28e-09: 62.8: 10.44
+	Hs
		203251 PACN1_HUMAN (4-377): 1.16e-40: 150: 14.58		SYNJ1_HUMAN (892-1118): 5.28e-09: 62.8: 10.44
+	Hs
		203224 MYO1E_HUMAN (252-377): 3.64e-25: 109: 33.33		SYNJ1_HUMAN (892-1118): 5.28e-09: 62.8: 10.44
+	Hs
		203218 GRB2_HUMAN (325-376): 4.64e-12: 66.8: 35.85		SYNJ1_HUMAN (892-1118): 5.28e-09: 62.8: 10.44