HitPredict

Interactor 1: SMC1 (P32908)
Structural maintenance of chromosomes protein 1 (DA-box protein SMC1)
Gene: SMC1

Interactor 2: SCC2 (Q04002)
Sister chromatid cohesion protein 2
Gene: SCC2

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.939

Property	Details
Experiments	34259632, 37739959, 14614819, 29932904, 35654035, 23499533
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Nipped-B_C~SMC_N
Common GO terms	GO:0005634 - nucleus GO:0006302 - double-strand break repair GO:0007064 - mitotic sister chromatid cohesion GO:0034087 - establishment of mitotic sister chromatid cohesion
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1225 Sc			1 1493
+	Sc
		758755 SMC2_YEAST (3-1216): 3.11e-76: 277: 16.23		SCC2_YEAST (1-1493): 0: 1921: 100.00
+	Sc
		810771 SMC3_YEAST (3-1221): 2.09e-67: 251: 15.88		SCC2_YEAST (1-1493): 0: 1921: 100.00
+	Mm
		1154101 SMC1A_MOUSE (1-1225): 2.91e-92: 325: 26.86		NIPBL_MOUSE (358-1387): 0: 1069: 18.85
+	Hs
		1057289 SMC1A_HUMAN (1-1225): 2.94e-92: 325: 26.86		NIPBL_HUMAN (358-1387): 0: 1063: 18.67
+	Mm
		1154102 SMC3_MOUSE (3-1222): 2.27e-74: 272: 16.89		NIPBL_MOUSE (358-1387): 0: 1069: 18.85
+	Hs
		1154087 SMC3_HUMAN (3-1222): 4.26e-74: 271: 16.89		NIPBL_HUMAN (358-1387): 0: 1063: 18.67
+	Sp
		293285 SMC1_SCHPO (1-1225): 1.54e-75: 276: 33.01		MIS4_SCHPO (277-1385): 0: 956: 22.13