HitPredict

Interactor 1: SMC1 (P32908)
Structural maintenance of chromosomes protein 1 (DA-box protein SMC1)
Gene: SMC1

Interactor 2: PDS5 (Q04264)
Sister chromatid cohesion protein PDS5 (Precocious dissociation of sisters protein 5)
Gene: PDS5

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

Property	Details
Experiments	17660750, 34259632, 21441928
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006302 - double-strand break repair GO:0007064 - mitotic sister chromatid cohesion GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1225 Sc			1 1277
+	Mm
		1118817 SMC1A_MOUSE (1-1225): 2.91e-92: 325: 26.86		PDS5B_MOUSE (3-1272): 0: 1249: 18.49
+	Hs
		1057405 SMC1A_HUMAN (1-1225): 2.94e-92: 325: 26.86		PDS5B_HUMAN (3-1272): 0: 1244: 18.31
+	Hs
		1057273 SMC1A_HUMAN (1-1225): 2.94e-92: 325: 26.86		PDS5A_HUMAN (4-1252): 0: 1216: 18.06
+	Mm
		93884 SMC1A_MOUSE (1-1225): 2.91e-92: 325: 26.86		E9QPI5_MOUSE (4-1265): 0: 1209: 17.95
+	Sc
		810772 SMC3_YEAST (3-1221): 2.09e-67: 251: 15.88		PDS5_YEAST (1-1277): 0: 1271: 100.00
+	Mm
		1149127 SMC1A_MOUSE (1-1225): 2.91e-92: 325: 26.86		PDS5A_MOUSE (4-1265): 0: 1192: 17.95
+	Hs
		1345702 SMC3_HUMAN (3-1222): 4.26e-74: 271: 16.89		PDS5B_HUMAN (3-1272): 0: 1244: 18.31
+	Xl
		292728 SMC1A_XENLA (1-1225): 1.18e-86: 309: 25.73		PD5BA_XENLA (2-1271): 0: 1203: 18.31
+	Xl
		292729 SMC1A_XENLA (1-1225): 1.18e-86: 309: 25.73		PD5AB_XENLA (5-1251): 0: 1202: 17.07
+	Xl
		292730 SMC1A_XENLA (1-1225): 1.18e-86: 309: 25.73		PD5AA_XENLA (3-1251): 0: 1200: 17.11
+	Hs
		1100586 SMC3_HUMAN (3-1222): 4.26e-74: 271: 16.89		PDS5A_HUMAN (4-1252): 0: 1216: 18.06
+	Xl
		292740 SMC3_XENLA (3-1222): 2e-74: 272: 16.84		PD5BB_XENLA (2-1271): 0: 1215: 18.38
+	Mm
		93885 SMC3_MOUSE (3-1222): 2.27e-74: 272: 16.89		E9QPI5_MOUSE (4-1265): 0: 1209: 17.95
+	Xl
		292738 SMC3_XENLA (3-1222): 2e-74: 272: 16.84		PD5BA_XENLA (2-1271): 0: 1203: 18.31
+	Xl
		1115499 Q8AW91_XENLA (3-1222): 1.01e-73: 270: 16.73		PD5BA_XENLA (2-1271): 0: 1203: 18.31
+	Xl
		1117310 Q8AW91_XENLA (3-1222): 1.01e-73: 270: 16.73		PD5AB_XENLA (5-1251): 0: 1202: 17.07
+	Xl
		292739 SMC3_XENLA (3-1222): 2e-74: 272: 16.84		PD5AA_XENLA (3-1251): 0: 1200: 17.11
+	Sp
		293288 SMC1_SCHPO (1-1225): 1.54e-75: 276: 33.01		PDS5_SCHPO (8-1196): 0: 978: 23.44
+	Sp
		193880 SMC3_SCHPO (3-1221): 2.95e-74: 271: 16.53		PDS5_SCHPO (8-1196): 0: 978: 23.44
+	Hs
		69118 SMC1A_HUMAN (1-1225): 2.94e-92: 325: 26.86		A9IYQ1_HUMAN (1077-1272): 5.56e-45: 166: 16.59