HitPredict

Interactor 1: IL3RB (P32927)
Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)
Gene: CSF2RB

Interactor 2: IL5RA (Q01344)
Interleukin-5 receptor subunit alpha (IL-5 receptor subunit alpha) (IL-5R subunit alpha) (IL-5R-alpha) (IL-5RA) (CDw125) (CD antigen CD125)
Gene: IL5RA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.60 0.60 0.601

The method score is based on:

Property Details
Experiments 9516124, 1495999
Identification Methods affinity chromatography technology, protein cross-linking with a bifunctional reagent, anti bait coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0004896 - cytokine receptor activity
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
GO:0009897 - external side of plasma membrane
GO:0019221 - cytokine-mediated signaling pathway
and 2 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 897
Hs

1 420
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024