HitPredict

Interactor 1: C2TA (P33076)
MHC class II transactivator (CIITA) (EC 2.3.1.-) (EC 2.7.11.1)
Gene: CIITA

Interactor 2: IRF8 (Q02556)
Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (H-ICSBP) (ICSBP)
Gene: IRF8

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	15242870, 21216962
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006955 - immune response GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1130 Hs			1 426
+	Hs
		702490 C2TA_HUMAN (1-1130): 0: 1032: 100.00		IRF4_HUMAN (6-386): 9.59e-150: 434: 43.96
+	Mm
		945410 C2TA_MOUSE (19-1130): 0: 903: 69.56		IRF4_MOUSE (6-386): 1.04e-150: 436: 43.27
+	Hs
		501004 C2TA_HUMAN (1-1130): 0: 1032: 100.00		IRF1_HUMAN (9-187): 2.59e-62: 206: 33.69
+	Hs
		536479 C2TA_HUMAN (1-1130): 0: 1032: 100.00		IRF2_HUMAN (9-167): 4.69e-53: 182: 36.88
+	Mm
		547395 C2TA_MOUSE (19-1130): 0: 903: 69.56		IRF1_MOUSE (9-186): 1.4e-58: 196: 32.09
+	Mm
		621180 C2TA_MOUSE (19-1130): 0: 903: 69.56		IRF2_MOUSE (9-167): 4.04e-52: 179: 36.25
+	Mm
		619025 NLRP3_MOUSE (834-1129): 1.35e-40: 165: 15.82		IRF8_MOUSE (1-426): 0: 579: 89.67