HitPredict

Interactor 1: CSTF2 (P33240)
Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64)
Gene: CSTF2

Interactor 2: SYMPK (Q92797)
Symplekin
Gene: SYMPK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.721

Property	Details
Experiments	10669729, 26496610, 29395067, 24981860, 33961781
Identification Methods	pull down, affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex GO:0016604 - nuclear body
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 577 Hs			1 1274
+	Hs
		1271061 CSTFT_HUMAN (1-576): 3.87e-55: 198: 67.64		SYMPK_HUMAN (1-1274): 0: 1736: 100.00
+	Dm
		1229165 Q9VE52_DROME (1-330): 2.62e-55: 194: 47.61		SYMPK_DROME (7-1132): 0: 1182: 35.75
+	Sc
		628795 RNA15_YEAST (16-88): 7.2e-16: 80.5: 47.95		PTA1_YEAST (49-739): 1.6e-93: 321: 15.01