HitPredict

Interactor 1: PRS6B (P33298)
26S proteasome regulatory subunit 6B homolog (Protein YNT1) (Tat-binding homolog 2)
Gene: RPT3

Interactor 2: RPN8 (Q08723)
26S proteasome regulatory subunit RPN8
Gene: RPN8

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.892

Property	Details
Experiments	11805837, 37968396, 16554755, 22195964
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	JAB~Prot_ATP_ID_OB, MitMem_reg~Prot_ATP_ID_OB
Common GO terms	GO:0000502 - proteasome complex GO:0006511 - ubiquitin-dependent protein catabolic process GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 428 Sc			1 338
+	At
		1320084 PRS4A_ARATH (44-419): 3.53e-159: 457: 46.83		PSD7B_ARATH (6-311): 1.9e-100: 300: 49.03
+	At
		188943 PRS4A_ARATH (44-419): 3.53e-159: 457: 46.83		PSD7A_ARATH (6-308): 6.55e-100: 298: 49.18
+	Dm
		640769 PRS4_DROME (17-427): 3.74e-136: 399: 44.10		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Sc
		771745 PRS4_YEAST (49-410): 4.56e-110: 332: 47.53		RPN8_YEAST (1-338): 6.52e-119: 348: 100.00
+	Dm
		640783 Q9V405_DROME (28-424): 1.01e-123: 366: 69.42		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Dm
		186102 PRS8_DROME (32-423): 7.65e-123: 364: 40.05		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Hs
		849176 PRS4_HUMAN (15-427): 5.03e-128: 378: 44.34		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Dm
		640797 Q9W414_DROME (41-426): 1.57e-121: 360: 39.90		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Hs
		798615 PRS6B_HUMAN (1-424): 2.6e-125: 371: 65.57		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Hs
		849179 PRS10_HUMAN (41-426): 2.56e-123: 364: 37.57		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Sp
		251457 PRS6B_SCHPO (40-428): 1.77e-119: 354: 77.89		RPN8_SCHPO (5-321): 6.04e-99: 296: 50.78
+	Hs
		849177 PRS8_HUMAN (30-423): 3.39e-120: 357: 39.59		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	At
		1339598 PRS4A_ARATH (44-419): 3.53e-159: 457: 46.83		PSDE_ARATH (3-263): 1.25e-46: 161: 17.65
+	Dm
		820501 PRS4_DROME (17-427): 3.74e-136: 399: 44.10		PSDE_DROME (3-264): 6.45e-48: 165: 16.90
+	Sp
		252271 PRS6B_SCHPO (40-428): 1.77e-119: 354: 77.89		RPN11_SCHPO (1-263): 3.34e-61: 199: 19.11
+	Sp
		736963 PRS4_SCHPO (49-419): 7.63e-113: 340: 49.33		RPN11_SCHPO (1-263): 3.34e-61: 199: 19.11
+	Dm
		1358669 Q9V405_DROME (28-424): 1.01e-123: 366: 69.42		PSDE_DROME (3-264): 6.45e-48: 165: 16.90
+	Dm
		186131 PRS8_DROME (32-423): 7.65e-123: 364: 40.05		PSDE_DROME (3-264): 6.45e-48: 165: 16.90
+	Dm
		1358678 Q9W414_DROME (41-426): 1.57e-121: 360: 39.90		PSDE_DROME (3-264): 6.45e-48: 165: 16.90