HitPredict

Interactor 1: B2RB89 (B2RB89)
cAMP-dependent protein kinase (EC 2.7.11.11)
Gene: PRKACB

Interactor 2: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 351 Hs			1 732
+	Hs
		431538 KAPCB_HUMAN (1-351): 1.47e-164: 464: 100.00		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		431511 KAPCA_HUMAN (1-351): 3.72e-164: 463: 92.88		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		431537 KAPCG_HUMAN (1-351): 5.62e-161: 456: 78.63		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		437900 KAPCB_HUMAN (1-351): 1.47e-164: 464: 100.00		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		437870 KAPCA_HUMAN (1-351): 3.72e-164: 463: 92.88		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		431573 AKT2_HUMAN (5-347): 1.05e-149: 432: 37.46		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		431548 KPCL_HUMAN (6-351): 1.63e-146: 430: 35.75		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		432376 AKT3_HUMAN (4-347): 2.95e-148: 428: 38.57		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		437898 KAPCG_HUMAN (1-351): 5.62e-161: 456: 78.63		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Mm
		432411 AKT1_MOUSE (2-347): 8.96e-148: 427: 39.32		HS90A_MOUSE (1-732): 0: 1083: 97.82
+	Hs
		437928 AKT2_HUMAN (5-347): 1.05e-149: 432: 37.46		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Mm
		513660 AKT1_MOUSE (2-347): 8.96e-148: 427: 39.32		HS90B_MOUSE (19-732): 0: 1063: 86.98
+	Hs
		437907 KPCL_HUMAN (6-351): 1.63e-146: 430: 35.75		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		438633 AKT3_HUMAN (4-347): 2.95e-148: 428: 38.57		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Bt
		964601 AKT1_BOVIN (2-347): 2.7e-148: 428: 39.60		HS90B_BOVIN (19-732): 0: 1059: 86.28
+	Hs
		538102 KAPCB_HUMAN (1-351): 1.47e-164: 464: 100.00		ENPL_HUMAN (14-701): 0: 898: 46.78
+	Hs
		538446 AKT3_HUMAN (4-347): 2.95e-148: 428: 38.57		ENPL_HUMAN (14-701): 0: 898: 46.78
+	Hs
		1123464 AKT3_HUMAN (4-347): 2.95e-148: 428: 38.57		H90B3_HUMAN (19-732): 0: 728: 65.41
+	Hs
		610732 KAPCB_HUMAN (1-351): 1.47e-164: 464: 100.00		H90B4_HUMAN (30-604): 0: 571: 62.61
+	Hs
		1123447 AKT3_HUMAN (4-347): 2.95e-148: 428: 38.57		H90B4_HUMAN (30-604): 0: 571: 62.61