HitPredict

Interactor 1: PRP8 (P33334)
Pre-mRNA-splicing factor 8
Gene: PRP8

Interactor 2: LSM2 (P38203)
U6 snRNA-associated Sm-like protein LSm2 (Small nuclear ribonucleoprotein D homolog SNP3)
Gene: LSM2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.892

Property	Details
Experiments	11805826, 16429126, 37968396, 16373487
Identification Methods	tandem affinity purification, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LSM~PRP8_domainIV
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005681 - spliceosomal complex GO:0005737 - cytoplasm GO:0046540 - U4/U6 x U5 tri-snRNP complex and 1 others more... GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 2413 Sc			1 95
+	Hs
		1159351 PRP8_HUMAN (52-2413): 0: 4464: 61.34		LSM2_HUMAN (1-95): 4.64e-40: 129: 63.16
+	Hs
		1159359 PRP8_HUMAN (52-2413): 0: 4464: 61.34		LSM4_HUMAN (1-95): 1.42e-35: 119: 29.90
+	Hs
		912661 PRP8_HUMAN (52-2413): 0: 4464: 61.34		SMD3_HUMAN (2-88): 1.96e-32: 111: 17.24
+	Hs
		912318 PRP8_HUMAN (52-2413): 0: 4464: 61.34		SMD1_HUMAN (1-95): 1.45e-26: 95.8: 27.37
+	Hs
		911871 PRP8_HUMAN (52-2413): 0: 4464: 61.34		RUXF_HUMAN (3-71): 1.74e-21: 82: 34.29
+	Sc
		704680 PRP8_YEAST (1-2413): 0: 4084: 100.00		SMD3_YEAST (2-88): 5.25e-29: 101: 17.24
+	Sc
		704674 PRP8_YEAST (1-2413): 0: 4084: 100.00		LSM4_YEAST (1-83): 6.06e-25: 93.9: 27.17