HitPredict

Interactor 1: PRP8 (P33334)
Pre-mRNA-splicing factor 8
Gene: PRP8

Interactor 2: RU17 (Q00916)
U1 small nuclear ribonucleoprotein 70 kDa homolog (U1 70K) (U1 snRNP 70 kDa homolog) (U1-70K) (U1 small nuclear ribonucleoprotein SNP1) (U1 snRNP protein SNP1)
Gene: SNP1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.680

Property	Details
Experiments	11425851, 11805837, 9630245
Identification Methods	two hybrid, coimmunoprecipitation, anti tag coimmunoprecipitation, affinity chromatography technology
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000395 - mRNA 5'-splice site recognition GO:0000398 - mRNA splicing, via spliceosome GO:0003729 - mRNA binding GO:0005634 - nucleus GO:0005681 - spliceosomal complex and 1 others more... GO:0030619 - U1 snRNA binding
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 2413 Sc			1 300
+	Hs
		442246 PRP8_HUMAN (52-2413): 0: 4464: 61.34		RU17_HUMAN (8-237): 2.03e-40: 147: 30.00
+	Hs
		1048109 PRP8_HUMAN (52-2413): 0: 4464: 61.34		HNRPD_HUMAN (72-194): 9.95e-30: 117: 24.00
+	Hs
		516560 PRP8_HUMAN (52-2413): 0: 4464: 61.34		PABP1_HUMAN (99-262): 8.85e-27: 111: 17.68
+	Sc
		376708 PRP8_YEAST (1-2413): 0: 4084: 100.00		PABP_YEAST (75-258): 9.92e-21: 94.1: 16.30