HitPredict

Interactor 1: PRP8 (P33334)
Pre-mRNA-splicing factor 8
Gene: PRP8

Interactor 2: SYF1 (Q04048)
Pre-mRNA-splicing factor SYF1 (PRP19-associated complex protein 90) (Synthetic lethal with CDC40 protein 1)
Gene: SYF1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.714

Property	Details
Experiments	11805826, 16554755, 16429126, 37968396, 21576257
Identification Methods	tandem affinity purification, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 2413 Sc			1 859
+	Hs
		1159295 PRP8_HUMAN (52-2413): 0: 4464: 61.34		SYF1_HUMAN (30-845): 1.94e-154: 476: 21.48
+	Hs
		1063231 PRP8_HUMAN (52-2413): 0: 4464: 61.34		SART3_HUMAN (398-838): 1.46e-44: 175: 13.31
+	Hs
		300184 PRP8_HUMAN (52-2413): 0: 4464: 61.34		PRP6_HUMAN (459-856): 1.36e-23: 109: 12.94
+	At
		98518 PRP8A_ARATH (44-2413): 0: 4454: 60.60		F4JZX8_ARATH (494-848): 9.54e-24: 109: 13.81
+	Hs
		1159278 PRP8_HUMAN (52-2413): 0: 4464: 61.34		CRNL1_HUMAN (8-269): 3.6e-11: 69.3: 18.80
+	At
		1338520 PRP8A_ARATH (44-2413): 0: 4454: 60.60		Q9LKU3_ARATH (391-859): 4.23e-12: 72.3: 10.30
+	Dm
		53429 A1Z8U0_DROME (60-2413): 0: 4388: 61.32		SYF1_DROME (67-572): 9.84e-18: 90.4: 9.65
+	Dm
		53435 A1Z8U0_DROME (60-2413): 0: 4388: 61.32		CRN_DROME (508-802): 6.99e-18: 90.4: 13.85
+	Sc
		586387 PRP8_YEAST (1-2413): 0: 4084: 100.00		PRP6_YEAST (157-799): 5.81e-22: 103: 12.19
+	Sp
		144959 SPP42_SCHPO (26-2413): 0: 4094: 60.18		PRP1_SCHPO (202-841): 1.62e-17: 89.7: 8.50
+	Sc
		704735 PRP8_YEAST (1-2413): 0: 4084: 100.00		CLF1_YEAST (4-377): 2.18e-12: 72.7: 11.71