HitPredict

Interactor 1: PRP8 (P33334)
Pre-mRNA-splicing factor 8
Gene: PRP8

Interactor 2: CLF1 (Q12309)
Pre-mRNA-splicing factor CLF1 (Crooked neck-like factor 1) (PRP19-associated complex protein 77) (Synthetic lethal with CDC40 protein 3)
Gene: CLF1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.691

Property	Details
Experiments	11805826, 16429126, 12509417, 37968396
Identification Methods	tandem affinity purification, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 2413 Sc			1 687
+	Hs
		1159278 PRP8_HUMAN (52-2413): 0: 4464: 61.34		CRNL1_HUMAN (5-685): 4.45e-115: 367: 36.61
+	At
		98518 PRP8A_ARATH (44-2413): 0: 4454: 60.60		F4JZX8_ARATH (5-686): 6.2e-114: 360: 33.24
+	Dm
		53435 A1Z8U0_DROME (60-2413): 0: 4388: 61.32		CRN_DROME (5-685): 4.64e-109: 347: 36.04
+	Dm
		53429 A1Z8U0_DROME (60-2413): 0: 4388: 61.32		SYF1_DROME (3-674): 1.7e-77: 267: 14.23
+	Hs
		1159295 PRP8_HUMAN (52-2413): 0: 4464: 61.34		SYF1_HUMAN (2-495): 4.59e-26: 116: 14.67
+	At
		1338520 PRP8A_ARATH (44-2413): 0: 4454: 60.60		Q9LKU3_ARATH (13-580): 5.24e-22: 103: 11.47
+	Hs
		1063231 PRP8_HUMAN (52-2413): 0: 4464: 61.34		SART3_HUMAN (21-387): 2.31e-11: 69.2: 15.08
+	Hs
		300184 PRP8_HUMAN (52-2413): 0: 4464: 61.34		PRP6_HUMAN (449-672): 5e-10: 64.9: 11.89
+	Sc
		704713 PRP8_YEAST (1-2413): 0: 4084: 100.00		SYF1_YEAST (54-674): 1.42e-57: 211: 11.97
+	Sp
		144959 SPP42_SCHPO (26-2413): 0: 4094: 60.18		PRP1_SCHPO (1-392): 2.83e-20: 98.1: 13.22
+	Sc
		586387 PRP8_YEAST (1-2413): 0: 4084: 100.00		PRP6_YEAST (28-198): 6.71e-10: 64.6: 13.30