HitPredict

Interactor 1: MYO9A (B2RTY4)
Unconventional myosin-IXa (Unconventional myosin-9a)
Gene: MYO9A

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	31871319, 20936779, 21311754, 16169070
Identification Methods	affinity chromatography technology, two hybrid, two hybrid pooling approach
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	C1_1~Ras, RA~Ras, Ras~RhoGAP
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane GO:0034329 - cell junction assembly GO:0045198 - establishment of epithelial cell apical/basal polarity
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 2548 Hs			1 191
+	Hs
		70663 MYO9A_HUMAN (1-2548): 0: 1625: 100.00		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		564757 MYO5A_HUMAN (93-1631): 0: 917: 20.36		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		1183623 MYO5A_HUMAN (93-1631): 0: 917: 20.36		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82
+	Hs
		724757 MYH9_HUMAN (93-1993): 0: 877: 17.46		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		724776 MYH9_HUMAN (93-1993): 0: 877: 17.46		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		925731 MYO6_HUMAN (142-688): 7e-109: 382: 38.57		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		894586 MYO6_HUMAN (142-688): 7e-109: 382: 38.57		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		901046 MYO6_HUMAN (142-688): 7e-109: 382: 38.57		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		545699 MYO6_HUMAN (142-688): 7e-109: 382: 38.57		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		1183609 MYO6_HUMAN (142-688): 7e-109: 382: 38.57		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82
+	Hs
		893974 MYO9B_HUMAN (1301-2470): 3.35e-86: 318: 23.29		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		900443 MYO9B_HUMAN (1301-2470): 3.35e-86: 318: 23.29		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		436289 MYO9B_HUMAN (1301-2470): 3.35e-86: 318: 23.29		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Ce
		93900 F0IWT2_CAEEL (860-1120): 1.67e-56: 220: 33.97		CDC42_CAEEL (1-191): 1.83e-79: 236: 86.39
+	Hs
		892610 MYO10_HUMAN (816-1063): 1.06e-28: 129: 28.99		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		925728 MYO5B_HUMAN (1428-2088): 1.37e-11: 72.7: 8.78		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31