HitPredict

Interactor 1: MYO9A (B2RTY4)
Unconventional myosin-IXa (Unconventional myosin-9a)
Gene: MYO9A

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	32203420, 31871319
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, RA~Ras, Ras~RhoGAP
Common GO terms	GO:0005829 - cytosol GO:0034329 - cell junction assembly GO:0045198 - establishment of epithelial cell apical/basal polarity
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2548 Hs			1 193
+	Hs
		70662 MYO9A_HUMAN (1-2548): 0: 1625: 100.00		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		70668 MYO9A_HUMAN (1-2548): 0: 1625: 100.00		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		120732 MYO5A_HUMAN (93-1631): 0: 917: 20.36		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98
+	Hs
		724757 MYH9_HUMAN (93-1993): 0: 877: 17.46		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		724776 MYH9_HUMAN (93-1993): 0: 877: 17.46		RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40
+	Hs
		901046 MYO6_HUMAN (142-688): 7e-109: 382: 38.57		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		925731 MYO6_HUMAN (142-688): 7e-109: 382: 38.57		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		894586 MYO6_HUMAN (142-688): 7e-109: 382: 38.57		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		545699 MYO6_HUMAN (142-688): 7e-109: 382: 38.57		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		916073 MYO6_HUMAN (142-688): 7e-109: 382: 38.57		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		120712 MYO6_HUMAN (142-688): 7e-109: 382: 38.57		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98
+	Hs
		900443 MYO9B_HUMAN (1301-2470): 3.35e-86: 318: 23.29		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		436289 MYO9B_HUMAN (1301-2470): 3.35e-86: 318: 23.29		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		893974 MYO9B_HUMAN (1301-2470): 3.35e-86: 318: 23.29		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		915654 MYO9B_HUMAN (1301-2470): 3.35e-86: 318: 23.29		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Ce
		93901 F0IWT2_CAEEL (860-1120): 1.67e-56: 220: 33.97		RHO1_CAEEL (1-192): 2.25e-75: 226: 85.94
+	Ce
		93900 F0IWT2_CAEEL (860-1120): 1.67e-56: 220: 33.97		CDC42_CAEEL (1-193): 2.41e-74: 223: 50.78
+	Hs
		892610 MYO10_HUMAN (816-1063): 1.06e-28: 129: 28.99		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		925728 MYO5B_HUMAN (1428-2088): 1.37e-11: 72.7: 8.78		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22