HitPredict

Interactor 1: CD80 (P33681)
T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD antigen CD80)
Gene: CD80

Interactor 2: PD1L1 (Q9NZQ7)
Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274)
Gene: CD274

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.86 1.00 0.928

The method score is based on:

Property Details
Experiments 21982860, 23417675, 20587542, 18585785, 31000591
Identification Methods pull down, surface plasmon resonance, protein array, cross-linking study
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains C2-set_2~C2-set_2, C2-set_2~V-set, V-set~V-set
Common GO terms GO:0005886 - plasma membrane
GO:0006955 - immune response
GO:0007166 - cell surface receptor signaling pathway
GO:0009897 - external side of plasma membrane
GO:0031295 - T cell costimulation
and 2 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 288
Hs

1 290
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024