HitPredict

Interactor 1: DCA13 (P33750)
Protein SOF1 (U3 small nucleolar RNA-associated protein SOF1) (U3 snoRNA-associated protein SOF1)
Gene: SOF1

Interactor 2: UTP7 (P40055)
U3 small nucleolar RNA-associated protein 7 (U3 snoRNA-associated protein 7) (U three protein 7)
Gene: UTP7

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

Property	Details
Experiments	18467557, 37968396
Identification Methods	protein complementation assay, affinity chromatography technology, dihydrofolate reductase reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Sof1~WD40, WD40~WD40
Common GO terms	GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0030490 - maturation of SSU-rRNA GO:0030686 - 90S preribosome and 1 others more... GO:0032040 - small-subunit processome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 489 Sc			1 554
+	Hs
		1281473 FBXW7_HUMAN (148-441): 5.72e-64: 222: 12.77		PRP19_HUMAN (50-386): 8.95e-83: 268: 17.66
+	Hs
		1309163 TBL1Y_HUMAN (89-448): 5.91e-65: 220: 12.70		TBL1R_HUMAN (171-463): 1.3e-53: 191: 10.76
+	Hs
		1240442 POC1A_HUMAN (161-476): 1.39e-67: 223: 12.77		POC1B_HUMAN (219-464): 3.33e-51: 184: 8.91
+	Hs
		245633 TBL1X_HUMAN (146-481): 9.23e-55: 194: 14.25		TBL1R_HUMAN (171-463): 1.3e-53: 191: 10.76
+	Hs
		245630 TBL1X_HUMAN (146-481): 9.23e-55: 194: 14.25		TBL1Y_HUMAN (188-465): 1.91e-52: 188: 11.92
+	Hs
		1310825 WDR83_HUMAN (59-381): 2.11e-26: 111: 18.49		PRP19_HUMAN (50-386): 8.95e-83: 268: 17.66
+	Hs
		903418 FBXW7_HUMAN (148-441): 5.72e-64: 222: 12.77		WDR5_HUMAN (167-386): 4.43e-33: 131: 14.41
+	Sp
		999838 TUP11_SCHPO (35-254): 9.5e-39: 150: 12.30		TUP11_SCHPO (215-464): 2.6e-47: 176: 11.81
+	Sp
		999842 TUP11_SCHPO (35-254): 9.5e-39: 150: 12.30		TUP12_SCHPO (9-263): 3.26e-43: 164: 9.89
+	Hs
		921751 NLE1_HUMAN (288-485): 3.92e-34: 135: 14.22		GBB2_HUMAN (55-260): 1.52e-40: 151: 12.62
+	Hs
		903551 NLE1_HUMAN (288-485): 3.92e-34: 135: 14.22		WDR5_HUMAN (167-386): 4.43e-33: 131: 14.41
+	Hs
		903077 WDR5_HUMAN (5-204): 4.35e-24: 104: 11.22		WDR5_HUMAN (167-386): 4.43e-33: 131: 14.41
+	Hs
		903349 WDR5B_HUMAN (3-204): 6.36e-24: 104: 9.76		WDR5_HUMAN (167-386): 4.43e-33: 131: 14.41
+	Hs
		196984 WDR5_HUMAN (5-204): 4.35e-24: 104: 11.22		PRP4_HUMAN (260-464): 1.76e-27: 118: 9.35
+	Hs
		1288273 WDR83_HUMAN (59-381): 2.11e-26: 111: 18.49		SNR40_HUMAN (42-176): 5.1e-14: 75.4: 9.79
+	Hs
		903428 WDR5_HUMAN (5-204): 4.35e-24: 104: 11.22		SNR40_HUMAN (42-176): 5.1e-14: 75.4: 9.79
+	Dm
		1358845 WDS_DROME (5-208): 1.88e-25: 109: 11.01		WDS_DROME (345-482): 3.57e-12: 70: 9.33
+	Hs
		792949 WDR5_HUMAN (5-204): 4.35e-24: 104: 11.22		LIS1_HUMAN (343-469): 3.51e-13: 73.5: 5.51