HitPredict

Interactor 1: PTPRB (B2RU80)
Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP)
Gene: PTPRB

Interactor 2: CADH5 (P55284)
Cadherin-5 (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144)
Gene: Cdh5

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	21857650, 12234928
Identification Methods	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, experimental interaction detection
Interaction Type	physical association, dephosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1998 Mm			1 784
+	Hs
		616903 PTPRB_HUMAN (1-1998): 0: 1309: 85.89		CADH5_HUMAN (31-783): 0: 734: 75.83
+	Hs
		580200 PTPRB_HUMAN (1-1998): 0: 1309: 85.89		CADH2_HUMAN (256-754): 5.39e-40: 160: 14.77
+	Hs
		521907 PTPRS_HUMAN (6-718): 7.14e-74: 276: 14.29		CADH1_HUMAN (18-780): 0: 632: 31.20
+	Hs
		489891 PTPRF_HUMAN (1-564): 1.15e-50: 200: 14.76		CADH1_HUMAN (18-780): 0: 632: 31.20
+	Hs
		521727 PTPRD_HUMAN (1-583): 1.46e-50: 200: 13.45		CADH1_HUMAN (18-780): 0: 632: 31.20
+	Hs
		702788 PTPRU_HUMAN (265-588): 1.51e-18: 95: 13.28		CADH5_HUMAN (31-783): 0: 734: 75.83
+	Hs
		521728 PTPRG_HUMAN (1728-1969): 5.71e-22: 106: 29.60		CADH1_HUMAN (18-780): 0: 632: 31.20
+	Hs
		521898 PTPRJ_HUMAN (1244-1607): 2.52e-19: 97.8: 14.21		CADH1_HUMAN (18-780): 0: 632: 31.20
+	Hs
		576981 PTPRA_HUMAN (1688-1967): 1.66e-102: 351: 35.23		CADH2_HUMAN (256-754): 5.39e-40: 160: 14.77
+	Hs
		617035 PTPRD_HUMAN (1-583): 1.46e-50: 200: 13.45		PCDG6_HUMAN (3-470): 1.08e-91: 309: 19.84
+	Hs
		617032 PTPRD_HUMAN (1-583): 1.46e-50: 200: 13.45		PCDGG_HUMAN (256-764): 4.71e-76: 266: 17.44
+	Hs
		617033 PTPRD_HUMAN (1-583): 1.46e-50: 200: 13.45		PCDB6_HUMAN (264-766): 1.53e-76: 265: 17.25
+	Rn
		1145482 PTPRF_RAT (1-590): 2.09e-54: 212: 15.10		CADH2_RAT (4-289): 4.05e-36: 148: 20.65
+	Hs
		490028 PTPRF_HUMAN (1-564): 1.15e-50: 200: 14.76		PCDBG_HUMAN (532-768): 2.18e-19: 95.3: 13.18
+	Hs
		617023 PTPRD_HUMAN (1-583): 1.46e-50: 200: 13.45		PCDBG_HUMAN (532-768): 2.18e-19: 95.3: 13.18
+	Dm
		183403 LAR_DROME (2-652): 1.99e-52: 206: 13.50		CADN_DROME (103-505): 9.82e-12: 71.2: 26.71
+	Hs
		441173 PTPRC_HUMAN (1704-1978): 5.29e-25: 116: 28.43		CADH2_HUMAN (256-754): 5.39e-40: 160: 14.77
+	Hs
		580201 PTPRG_HUMAN (1728-1969): 5.71e-22: 106: 29.60		CADH2_HUMAN (256-754): 5.39e-40: 160: 14.77
+	Hs
		580229 PTPRJ_HUMAN (1244-1607): 2.52e-19: 97.8: 14.21		CADH2_HUMAN (256-754): 5.39e-40: 160: 14.77
+	Rn
		94056 F1LPJ1_RAT (7-335): 4.88e-19: 97: 13.22		CADH2_RAT (4-289): 4.05e-36: 148: 20.65