HitPredict

Interactor 1: S10A5 (P33763)
Protein S100-A5 (Protein S-100D) (S100 calcium-binding protein A5)
Gene: S100A5

Interactor 2: TRPM4 (Q8TD43)
Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4)
Gene: TRPM4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	31837246
Identification Methods	fluorescence polarization spectroscopy, isothermal titration calorimetry
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0043025 - neuronal cell body
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 92 Hs			1 1214
+	Hs
		615221 S10A1_HUMAN (1-91): 7.55e-35: 116: 43.62		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		685179 S10AB_HUMAN (2-89): 8.25e-34: 113: 32.97		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		639026 S100P_HUMAN (3-89): 3.71e-31: 106: 37.78		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		642972 S10A4_HUMAN (1-87): 2.38e-30: 104: 51.11		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		893818 S10AA_HUMAN (1-92): 3.59e-30: 104: 30.53		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		416480 S10A9_HUMAN (3-92): 2.73e-29: 102: 31.92		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		661361 S10A2_HUMAN (1-87): 2.13e-29: 102: 51.11		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		396768 S10A8_HUMAN (1-91): 7.67e-29: 100: 30.77		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		707382 S10A3_HUMAN (1-87): 7.7e-28: 98.3: 41.11		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		380818 S100B_HUMAN (3-90): 1.67e-27: 97.2: 39.56		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		416665 S10A6_HUMAN (1-87): 4.42e-27: 96: 52.27		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		1254558 S10AE_HUMAN (3-81): 8.19e-23: 85.6: 24.05		TRPM4_HUMAN (1-1214): 0: 1243: 100.00