HitPredict

Interactor 1: S10A3 (P33764)
Protein S100-A3 (Protein S-100E) (S100 calcium-binding protein A3)
Gene: S100A3

Interactor 2: S100Z (Q8WXG8)
Protein S100-Z (S100 calcium-binding protein Z)
Gene: S100Z

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	S_100~S_100
Common GO terms	GO:0005509 - calcium ion binding GO:0048306 - calcium-dependent protein binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 101 Hs			1 99
+	Hs
		1135040 Q5T7Y6_HUMAN (1-90): 9.99e-40: 130: 42.22		Q5T7Y6_HUMAN (1-94): 1.52e-41: 134: 57.45
+	Hs
		615203 S10A4_HUMAN (1-98): 8.11e-38: 124: 45.92		S10A1_HUMAN (1-94): 6.61e-38: 124: 57.45
+	Mm
		421246 S10A4_MOUSE (1-98): 1.44e-38: 126: 48.98		S10A1_MOUSE (1-94): 3.95e-37: 121: 56.38
+	Hs
		615200 S10A1_HUMAN (1-90): 8.76e-38: 123: 42.22		S10A1_HUMAN (1-94): 6.61e-38: 124: 57.45
+	Hs
		638981 Q5T7Y6_HUMAN (1-90): 9.99e-40: 130: 42.22		S100P_HUMAN (3-93): 1.58e-34: 115: 51.65
+	Hs
		615222 S10A1_HUMAN (1-90): 8.76e-38: 123: 42.22		S100Z_HUMAN (1-99): 5.04e-36: 119: 100.00
+	Hs
		615201 S10A1_HUMAN (1-90): 8.76e-38: 123: 42.22		S100P_HUMAN (3-93): 1.58e-34: 115: 51.65
+	Mm
		421245 S10A4_MOUSE (1-98): 1.44e-38: 126: 48.98		S10A4_MOUSE (1-90): 8.4e-33: 111: 45.56
+	Hs
		380790 Q5T7Y6_HUMAN (1-90): 9.99e-40: 130: 42.22		S100B_HUMAN (3-93): 1.16e-30: 105: 45.06
+	Hs
		642915 S10A4_HUMAN (1-98): 8.11e-38: 124: 45.92		S10A4_HUMAN (1-90): 7.21e-33: 111: 46.67
+	Hs
		642916 S10A4_HUMAN (1-98): 8.11e-38: 124: 45.92		S10A2_HUMAN (1-92): 2.41e-32: 109: 42.39
+	Hs
		615204 S10A1_HUMAN (1-90): 8.76e-38: 123: 42.22		S10A2_HUMAN (1-92): 2.41e-32: 109: 42.39
+	Hs
		661208 S10A3_HUMAN (1-101): 2.8e-37: 122: 100.00		S10A2_HUMAN (1-92): 2.41e-32: 109: 42.39
+	Hs
		380739 S10A4_HUMAN (1-98): 8.11e-38: 124: 45.92		S100B_HUMAN (3-93): 1.16e-30: 105: 45.06
+	Hs
		615206 S10A1_HUMAN (1-90): 8.76e-38: 123: 42.22		S10A3_HUMAN (1-90): 6.14e-31: 106: 37.78
+	Hs
		380736 S10A1_HUMAN (1-90): 8.76e-38: 123: 42.22		S100B_HUMAN (3-93): 1.16e-30: 105: 45.06
+	Hs
		707354 S10A3_HUMAN (1-101): 2.8e-37: 122: 100.00		S10A3_HUMAN (1-90): 6.14e-31: 106: 37.78
+	Hs
		416574 S10A4_HUMAN (1-98): 8.11e-38: 124: 45.92		S10A6_HUMAN (1-90): 1.58e-27: 97.6: 38.89