HitPredict

Interactor 1: H2B1B (P33778)
Histone H2B type 1-B (H2B-clustered histone 3) (Histone H2B.1) (Histone H2B.f) (H2B/f)
Gene: H2BC3

Interactor 2: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.853

Property	Details
Experiments	24457600, 33589814, 34316702
Identification Methods	affinity chromatography technology, enzymatic study, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Histone~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 126 Hs			1 326
+	Hs
		717877 H2B2E_HUMAN (1-126): 7.04e-55: 169: 98.41		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Hs
		717646 H2B1C_HUMAN (1-126): 1.27e-54: 168: 97.62		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Hs
		717607 H2B1D_HUMAN (1-126): 2.89e-54: 167: 97.62		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Hs
		718401 H2B2E_HUMAN (1-126): 7.04e-55: 169: 98.41		PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36
+	Hs
		1087375 H2B2E_HUMAN (1-126): 7.04e-55: 169: 98.41		PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33
+	Hs
		918649 H2B1C_HUMAN (1-126): 1.27e-54: 168: 97.62		PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33
+	Hs
		1087359 H2B2E_HUMAN (1-126): 7.04e-55: 169: 98.41		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		707723 H2B1B_HUMAN (1-126): 1.3e-54: 168: 100.00		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		918631 H2B1C_HUMAN (1-126): 1.27e-54: 168: 97.62		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		1231231 H2B3B_HUMAN (1-126): 2.37e-52: 163: 96.03		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Mm
		1145466 H2B2E_MOUSE (1-126): 1.56e-53: 165: 95.24		CHFR_MOUSE (6-167): 1.07e-33: 132: 19.39
+	Hs
		707600 H2B1B_HUMAN (1-126): 1.3e-54: 168: 100.00		RING1_HUMAN (7-115): 2.38e-30: 120: 25.46
+	Hs
		918311 H2B1C_HUMAN (1-126): 1.27e-54: 168: 97.62		RING1_HUMAN (7-115): 2.38e-30: 120: 25.46
+	Hs
		282669 H2B2E_HUMAN (1-126): 7.04e-55: 169: 98.41		RNF8_HUMAN (2-101): 3.38e-21: 95.7: 25.00
+	Hs
		282550 H2B1B_HUMAN (1-126): 1.3e-54: 168: 100.00		RNF8_HUMAN (2-101): 3.38e-21: 95.7: 25.00
+	Mm
		1145467 H2B2E_MOUSE (1-126): 1.56e-53: 165: 95.24		RNF8_MOUSE (2-102): 4.69e-20: 92.2: 26.73