HitPredict

Interactor 1: H2B1B (P33778)
Histone H2B type 1-B (H2B-clustered histone 3) (Histone H2B.1) (Histone H2B.f) (H2B/f)
Gene: H2BC3

Interactor 2: BRE1A (Q5VTR2)
E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A)
Gene: RNF20

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.689

Property	Details
Experiments	19410543, 37633270, 35938192, 37102239
Identification Methods	enzymatic study, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 975
+	Hs
		1087184 H2B2E_HUMAN (1-126): 7.04e-55: 169: 98.41		BRE1A_HUMAN (1-975): 1.48e-77: 275: 100.00
+	Mm
		1125390 H2B1B_MOUSE (1-126): 5.1e-53: 164: 97.62		BRE1A_MOUSE (1-975): 9.63e-75: 267: 97.54
+	Hs
		256269 H2B2E_HUMAN (1-126): 7.04e-55: 169: 98.41		BRE1B_HUMAN (1-974): 4.61e-62: 230: 56.49
+	Hs
		256219 H2B1B_HUMAN (1-126): 1.3e-54: 168: 100.00		BRE1B_HUMAN (1-974): 4.61e-62: 230: 56.49
+	Hs
		1274476 H2B1H_HUMAN (1-126): 6.88e-55: 169: 96.83		MYH2_HUMAN (201-955): 6.17e-36: 150: 13.16
+	Hs
		724951 H2B1H_HUMAN (1-126): 6.88e-55: 169: 96.83		MYH9_HUMAN (235-957): 1.06e-32: 139: 11.26
+	Hs
		241463 H2B1K_HUMAN (1-126): 1.48e-54: 168: 96.83		MYH9_HUMAN (235-957): 1.06e-32: 139: 11.26
+	Hs
		724751 H2B1C_HUMAN (1-126): 1.27e-54: 168: 97.62		MYH9_HUMAN (235-957): 1.06e-32: 139: 11.26
+	Hs
		724734 H2B1D_HUMAN (1-126): 2.89e-54: 167: 97.62		MYH9_HUMAN (235-957): 1.06e-32: 139: 11.26
+	Hs
		254485 H2B2E_HUMAN (1-126): 7.04e-55: 169: 98.41		ROCK2_HUMAN (96-897): 2.15e-15: 83.5: 14.08
+	Hs
		148290 H2B1J_HUMAN (1-126): 8.38e-55: 169: 97.62		CTRO_HUMAN (49-890): 9.97e-15: 81.5: 14.94
+	Hs
		241465 H2B1K_HUMAN (1-126): 1.48e-54: 168: 96.83		MYH11_HUMAN (586-956): 8.4e-15: 81.7: 11.61
+	Hs
		728463 H2B1C_HUMAN (1-126): 1.27e-54: 168: 97.62		MYH11_HUMAN (586-956): 8.4e-15: 81.7: 11.61
+	Hs
		148194 H2B1K_HUMAN (1-126): 1.48e-54: 168: 96.83		CTRO_HUMAN (49-890): 9.97e-15: 81.5: 14.94
+	Hs
		148588 H2BFS_HUMAN (1-126): 1.19e-54: 168: 95.24		CTRO_HUMAN (49-890): 9.97e-15: 81.5: 14.94
+	Hs
		725214 H2B1H_HUMAN (1-126): 6.88e-55: 169: 96.83		MYH10_HUMAN (604-944): 1.39e-12: 74.4: 10.85
+	Hs
		241464 H2B1K_HUMAN (1-126): 1.48e-54: 168: 96.83		MYH10_HUMAN (604-944): 1.39e-12: 74.4: 10.85
+	Hs
		725133 H2B1C_HUMAN (1-126): 1.27e-54: 168: 97.62		MYH10_HUMAN (604-944): 1.39e-12: 74.4: 10.85
+	Hs
		725122 H2B1D_HUMAN (1-126): 2.89e-54: 167: 97.62		MYH10_HUMAN (604-944): 1.39e-12: 74.4: 10.85
+	Hs
		551798 H2B1H_HUMAN (1-126): 6.88e-55: 169: 96.83		DESP_HUMAN (225-919): 9.01e-12: 71.9: 16.12