HitPredict

Interactor 1: TTK (P33981)
Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT)
Gene: TTK

Interactor 2: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 857 Hs			1 196
+	Hs
		925307 PKN1_HUMAN (49-854): 5.4e-155: 480: 13.90		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		900513 PKN1_HUMAN (49-854): 5.4e-155: 480: 13.90		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		915705 PKN1_HUMAN (49-854): 5.4e-155: 480: 13.90		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		925308 PKN2_HUMAN (49-854): 1e-151: 472: 14.24		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		900514 PKN2_HUMAN (49-854): 1e-151: 472: 14.24		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		915706 PKN2_HUMAN (49-854): 1e-151: 472: 14.24		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		545401 PKN2_HUMAN (49-854): 1e-151: 472: 14.24		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		436326 PKN2_HUMAN (49-854): 1e-151: 472: 14.24		RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16
+	Hs
		951021 PKN2_HUMAN (49-854): 1e-151: 472: 14.24		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		894056 PKN2_HUMAN (49-854): 1e-151: 472: 14.24		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		900594 PKN3_HUMAN (49-854): 3.01e-144: 450: 14.95		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		915766 PKN3_HUMAN (49-854): 3.01e-144: 450: 14.95		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		120458 PKN2_HUMAN (49-854): 1e-151: 472: 14.24		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98
+	Ce
		107919 G5EFX2_CAEEL (61-854): 1.36e-133: 425: 13.31		RAC1_CAEEL (1-196): 5.29e-80: 238: 53.57
+	Ce
		104463 G5EFX2_CAEEL (61-854): 1.36e-133: 425: 13.31		G5EBV3_CAEEL (2-196): 7.03e-76: 227: 48.72
+	Ce
		107920 G5EFX2_CAEEL (61-854): 1.36e-133: 425: 13.31		RHO1_CAEEL (1-196): 4.36e-75: 225: 78.57
+	Hs
		296515 KPCD3_HUMAN (174-853): 3.32e-129: 411: 15.32		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		915949 KPCD2_HUMAN (140-855): 7.56e-120: 386: 14.74		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		277602 PAK3_HUMAN (237-800): 8.99e-122: 381: 18.42		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		277599 PAK3_HUMAN (237-800): 8.99e-122: 381: 18.42		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49