HitPredict

Interactor 1: TTK (P33981)
Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT)
Gene: TTK

Interactor 2: LPAR4 (Q99677)
Lysophosphatidic acid receptor 4 (LPA receptor 4) (LPA-4) (G-protein coupled receptor 23) (P2Y purinoceptor 9) (P2Y9) (P2Y5-like receptor) (Purinergic receptor 9)
Gene: LPAR4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.80	0.726

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	7tm_1~Pkinase
Common GO terms	-
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 857 Hs			1 370
+	Hs
		708278 TTK_HUMAN (1-857): 0: 776: 100.00		CXCR4_HUMAN (31-319): 1.02e-85: 265: 29.11
+	Hs
		708264 TTK_HUMAN (1-857): 0: 776: 100.00		APJ_HUMAN (17-370): 5.13e-70: 225: 25.14
+	Hs
		708266 TTK_HUMAN (1-857): 0: 776: 100.00		OPRX_HUMAN (5-364): 7e-70: 225: 22.87
+	Hs
		708289 TTK_HUMAN (1-857): 0: 776: 100.00		GPR17_HUMAN (21-353): 2.59e-67: 218: 29.04
+	Hs
		126570 TTK_HUMAN (1-857): 0: 776: 100.00		P2Y10_HUMAN (25-319): 1.42e-46: 163: 34.34
+	Hs
		566331 KPCA_HUMAN (367-850): 2.8e-118: 375: 14.94		CCR3_HUMAN (36-370): 3.67e-81: 253: 25.67
+	Hs
		850652 KS6A3_HUMAN (477-818): 6.94e-81: 277: 21.05		P2RY6_HUMAN (30-320): 9.19e-40: 145: 32.10
+	Hs
		1031129 M3K4_HUMAN (530-795): 2.19e-22: 105: 27.47		GPR17_HUMAN (21-353): 2.59e-67: 218: 29.04