HitPredict

Interactor 1: MCM4 (P33991)
DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21)
Gene: MCM4

Interactor 2: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	27173435, 15654075, 31730000
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 863 Hs			1 603
+	Xl
		936130 MCM4A_XENLA (1-863): 0: 931: 85.63		PLK1_XENLA (21-603): 0: 590: 80.38
+	Hs
		832257 MCM2_HUMAN (2-839): 0: 762: 27.95		PLK1_HUMAN (1-603): 0: 617: 100.00
+	Xl
		879168 MCM2_XENLA (13-839): 0: 770: 27.77		PLK1_XENLA (21-603): 0: 590: 80.38
+	Hs
		708584 MCM5_HUMAN (133-846): 0: 698: 30.23		PLK1_HUMAN (1-603): 0: 617: 100.00
+	Hs
		861754 MCM6_HUMAN (138-842): 0: 675: 26.97		PLK1_HUMAN (1-603): 0: 617: 100.00
+	Hs
		708848 MCM7_HUMAN (158-841): 0: 660: 29.88		PLK1_HUMAN (1-603): 0: 617: 100.00
+	Xl
		936129 MC6ZA_XENLA (137-852): 0: 678: 28.18		PLK1_XENLA (21-603): 0: 590: 80.38
+	Xl
		936138 MCM7A_XENLA (158-841): 0: 646: 31.16		PLK1_XENLA (21-603): 0: 590: 80.38